The Rat microRNA body atlas; Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dog

Table 1 Rat tissue specific miRNAs

Tissue	miRNA
Adrenal	miR-126b, miR-494-5p, mir-134-pre, miR-3544, miR-299a-5p;miR-299b-5p
Brainstem	miR-296-3p, miR-7047-3p, miR-186-3p
Cerebellum	mir-1928-pre, mir-484-pre, miR-130a-3p;miR-130b-3p, miR-6125, miR-154-3p
Cerebrum	miR-218-5p, miR-466i-5p;mir-466 k-pre;mir-466q-pre, miR-410-5p, miR-344 g, mir-504-pre, miR-344b-1-3p;miR-344b-2-3p, miR-551b-5p, miR-103-2-5p
Heart	miR-208a-3p, miR-208a-5p, miR-126-3p, miR-6314, miR-509-3p
Ileum	miR-2137, miR-3195, miR-320-5p, miR-4448
Liver	miR-101b-5p, miR-122-3p, miR-1195, miR-466c-3p, miR-293-5p, miR-466b-2-3p;miR-466c-3p;mir-466d-pre, miR-692, miR-466b-2-3p, mir-328-pre, miR-466f-3p, mir-5131-pre
Medulla	miR-200b-3p;miR-429
Muscle Biceps	miR-675-5p
Muscle Soleus	miR-206-5p, miR-1273 g-3p;mir-1273a-pre
Pancreas	miR-320c, miR-148b-3p;miR-152-3p
Whole Blood	mir-466q-pre, miR-7687-5p, miR-3656;mir-3195-pre, miR-3473b;mir-3473d-pre, miR-6937-5p

Tissue specific miRNAs were defined as miRNAs there are expressed at a raw count of >1 in 8/10 rats in 1 tissue only. Sequencing data was analyzed by non-negative matrix factorization which identified tissue specific miRNAs. Organs not listed in the table did not have tissue specific miRNAs

ISSN: 1471-2164