From: AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer
Canonical 10-top-output_mixeda | Canonical output_individualb | Related studiesc | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
APOBEC3G | ESR1 | ID2 | ID3 | PTPRC (CD45) | |||||||||||
Pos. | Canonical pathways | P-value | Molecules | Pos. | Molecules | Pos. | Molecules | Pos. | Molecules | Pos. | Molecules | Pos. | Molecules | Ovarian Cancer | Others |
1 | Hepatic Fibrosis / Hepatic Stellate Cell Activation | 8.32E-08 | COL1A1, IGFBP4, CCR5, FN1, CTGF, TIMP1, ACTA2, IL10RA, CCL5, FAS, EGFR | Â | Â | Â | Â | 1 | COL1A1, IGFBP4, CTGF, TIMP1, ACTA2, FAS, EGFR | 5 | IGFBP4, FN1 | 14 | CCR5, IL10RA, CCL5 | [81] | |
2 | Altered T Cell and B Cell Signaling in Rheumatoid Arthritis | 1.51E-06 | HLA-DOA, IL15, TLR8, FCER1G, CD86, TLR3, TNFSF13B, FAS | 3 | HLA-DOA, IL15, TLR3, TNFSF13B | Â | Â | Â | Â | Â | Â | 6 | TLR8, FCER1G, CD86 | Â | [83] |
3 | Antigen Presentation Pathway | 2.40E-05 | PSMB9, HLA-DOA, CIITA, HLA-DPB1, HLA-DPA1 | 1 | PSMB9, HLA-DOA, CIITA, HLA-DPB1, HLA-DPA1 | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
4 | Communication between Innate and Adaptive Immune Cells | 2.45E-05 | IL15, TLR8, FCER1G, CD86, CCL5, TLR3, TNFSF13B | 4 | IL15, CCL5, TLR3, TNFSF13B | Â | Â | Â | Â | Â | Â | 1 | TLR8, FCER1G, CD86, CCL5 | [100] | Â |
5 | Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | 3.47E-05 | IFIH1, CLEC7A, TLR8, CASP1, CCL5, TLR3, C3AR1 | 2 | IFIH1, CLEC7A, CASP1, CCL5, TLR3 | Â | Â | Â | Â | Â | Â | 9 | TLR8, CCL5, C3AR1 | Â | |
6 | Allograft Rejection Signaling | 1.35E-04 | HLA-DOA, FCER1G, CD86, HLA-DPB1, HLA-DPA1, FAS | 6 | HLA-DOA, HLA-DPB1, HLA-DPA1 | Â | Â | Â | Â | Â | Â | 25 | FCER1G, CD86 | Â | [104] |
7 | Crosstalk between Dendritic Cells and Natural Killer Cells | 2.09E-04 | CSF2RB, ACTA2, IL15, CD86, TLR3, FAS | 21 | IL15, TLR3 | Â | Â | 40 | ACTA2,FAS | Â | Â | 27 | CSF2RB, CD86 | Â | |
8 | CCR5 Signaling in Macrophages | 5.25E-04 | CCR5, FCER1G, CCL5, GNG12, FAS | Â | Â | Â | Â | 27 | GNG12, FAS | Â | Â | 4 | CCR5, FCER1G, CCL5 | [109] | |
9 | CD28 Signaling in T Helper Cells | 8.13E-04 | PTPRC, HLA-DOA, FCER1G, CD86, ITPR1, LCP2 | Â | Â | Â | Â | Â | Â | Â | Â | 2 | PTPRC, FCER1G, CD86, LCP2 | Â | |
10 | Graft-versus-Host Disease Signaling | 9.12E-04 | HLA-DOA, FCER1G, CD86, FAS | Â | Â | Â | Â | Â | Â | Â | Â | 16 | FCER1G, CD86 | Â | [112] |