Fig. 1From: Exploring the nature of prediagnostic blood transcriptome markers of chronic lymphocytic leukemia by assessing their overlap with the transcriptome at the clinical stageGraphical representation of the approach followed to assess the overlap of gene-expression markers identified in the prediagnostic study with gene-expression markers identified in the clinical study. Based on the overlap between the prediagnostic study and clinical studies, four main categories were defined: consistently upregulated (++), consistently downregulated (−−), dissimilar (+−, +o, −o, o-, o+, −+), or consistently non-significant (oo). The first and second symbols relate to clinical and prediagnostic data respectively, and ‘+’ indicates a positive association, ‘-’ an inverse association, and ‘o’ a non-significant association. A gene was considered differentially expressed in both sections (‘++’ or ‘--’) if it reached Bonferroni-corrected 5% statistical significance in at least one of the two types of studies, and reached nominal 0.05 significance in the other study type. Any gene not reaching Bonferroni 5% statistical significance in either type of study is considered as a null finding (‘oo’)Back to article page