Fig. 1
From: Detect tissue heterogeneity in gene expression data with BioQC
Results of simulation studies a Speed benchmark. Left panel: running time of BioQC and R-native Wilcoxon test with simulated datsets of increasing sample sizes. Right panel: ratio of running time between the two implementations. b Sensitivity of BioQC revealed by simulations with model-generated data. Left panel: whisker-box-plot of BioQC enrichment scores of the selected gene set (Y-axis) against the average expression differences of genes in the set compared with genes not in the set (X-axis). Right panel: whisker-box-plot of ranks of enrichment scores. c Sensitivity of BioQC revealed by simulations with real-world data. Left panel: Enrichment scores of cardiac-muscle- and small-intestine-enriched genes as canine heart and jejunum samples are mixed with varying weights. Right panel: Ranks of enrichment scores plotted against varying weights