Method | Standard Deleterious Threshold | Threshold for Mutation Severity Score of 1 | Threshold for Mutation Severity Score of 2 |
---|---|---|---|
SIFT | Score < 0.05 | Score > 0.025 | Score ≤ 0.025 |
PolyPhen2 | Score ≥ 0.5 | Score < 0.80 | Score ≥ 0.80 |
Mutation Assessor | Score > 1.9 | Score < 2.7 | Score ≥ 2.7 |
FATHMM | Score ≤ −1.5 | Score ≥ −8.5 | Score < −8.5 |
Condel | Score > 0.522 | Score ≤ 0.672 | Score > 0.672 |
CADD | Score ≥ 15 | Score < 27.5 | Score ≥ 27.5 |