Identification of common oncogenic and early developmental pathways in the ovarian carcinomas controlling by distinct prognostically significant microRNA subsets

Table 4 Multivariate Cox proportional hazards analysis of the prognostic 19-miRNA prognostic predictor of HG-SOC patients

Variable	Characteristics	HR	95% CI	P-value
SWVg–derived 19 miRNA signature: three groups	low risk group	1
	intermediate risk group	1.80	1.30-2.50	4.00E-04
	high risk group	5.39	2.68-10.84	2.37E-06
tumor residual disease	1-10 mm	1
	11-20 mm	0.98	0.53-1.78	0.94
	>20 mm	0.93	0.64-1.36	0.72
	No macroscopic disease	0.50	0.31-0.81	4.78E-03
tumor stage	low (stage I, II)	1
tumor stage	high (stage III, IV)	1.87	0.74-4.72	0.19
tumor grade	low (grade 1, 2)	1
tumor grade	high (grade 3, 4)	1.41	0.90-2.20	0.14

Note: Results were obtained from the analysis of the HG-SOC TCGA dataset. HR: hazard ratio, CI: confidence interval

ISSN: 1471-2164