Table 2 Enriched functions of DE genes in Down and Up group using IPA (89% grain vs. 72% grain)
Enriched functions | p-Value | Z-score | Molecules |
|---|---|---|---|
Down group | |||
Immune response of leukocytes | 1.14E-02 | −2.2 | C3, CXCL8, FCGR2B, IL1B, ISG15 |
Attraction of phagocytes | 7.33E-05 | −2.2 | C3, CXCL5, CXCL8, IL1B, VCAN |
Attraction of myeloid cells | 5.73E-05 | −2.2 | C3, CXCL5, CXCL8, IL1B, VCAN |
Cell movement of leukocytes | 4.17E-02 | −2.0 | C3, CXCL5, CXCL8, FOS, IL1B, S100A9, VCAN |
Infection of cells | 2.35E-03 | −2.0 | C2, C3, EIF2AK2, FCGR2B |
Stimulation of leukocytes | 1.18E-02 | −2.0 | C3, CXCL5, CXCL8, IL1B |
Quantity of Ca2+ | 4.61E-03 | −2.0 | C3, CXCL8, IL1B, S100A9 |
Adhesion of neutrophils | 2.42E-03 | −2.0 | C3, CXCL8, IL1B, S100A9 |
Apoptosis of macrophages | 3.86E-03 | −2.0 | EIF2AK2, FOS, IL1B, ISG15 |
Activation of granulocytes | 5.11E-03 | −1.9 | C3, CXCL8, FCGR2B, IL1B |
Viral Infection | 5.73E-05 | −1.9 | C2, C3, CXCL8, EGR1, EIF2AK2, FCGR2B, IL1B, MX1, S100A9 |
Binding of leukocytes | 1.39E-02 | −1.8 | A2M, C3, CXCL8, FCGR2B, IL1B, S100A9 |
Fatty acid metabolism | 1.78E-03 | −1.8 | CXCL8, CYP3A4, FABP4, FCGR2B, IL1B |
Apoptosis of leukocytes | 1.14E-02 | −1.8 | CXCL8, EGR1, EIF2AK2, FCGR2B, FOS, IL1B, ISG15 |
Cell death of immune cells | 1.78E-03 | −1.7 | C3, CXCL8, EGR1, EIF2AK2, FABP4, FCGR2B, FOS, IL1B, ISG15, MX1, MYH11 |
Degranulation of phagocytes | 1.57E-04 | −1.7 | C3, CXCL8, DUSP1, FCGR2B, FOS, IL1B, S100A9 |
Adhesion of immune cells | 2.77E-02 | −1.6 | A2M, C3, CXCL8, IL1B, S100A9 |
Binding of professional phagocytic cells | 5.75E-03 | −1.6 | A2M, C3, CXCL8, IL1B, S100A9 |
Mobilization of Ca2+ | 1.14E-02 | −1.6 | A2M, C3, CXCL8, FCGR2B |
Migration of phagocytes | 5.28E-03 | −1.6 | C3, CXCL5, CXCL8, IL1B, S100A9, VCAN |
Migration of granulocytes | 2.35E-03 | −1.5 | C3, CXCL5, CXCL8, IL1B, S100A9 |
Up group | |||
Concentration of lipid | 8.12E-02 | −2.0 | ABCA1, CXCL8, CYP1A1, CYP1B1, S100A9 |
Proliferation of epithelial cells | 9.40E-02 | −1.8 | CAV1, CDC25B, CXCL8, EDN1, FLT1, FOS, FRS2, GLI1, KRAS, KRT16, MKI67, NR3C1, ODC1, PTHLH, SULF2 |
Recruitment of neutrophils | 7.13E-02 | −1.6 | CAV1, CXCL2, CXCL5, CXCL8, CYP1A1, CYP1B1, EDN1, P2RY2 |
Quantity of T lymphocytes | 1.15E-01 | 1.5 | ACKR4, BIRC5, CCNB2, CD48, FOS, IL6ST, KRAS, LGALS1, MYH11, MYSM1, NR3C1, PTTG1, TACC3, TGFBR1, TSC1, XIAP |
Differentiation of epithelial cells | 7.13E-02 | 1.7 | AURKB, CAV1, DSG1, E2F8, EDN1, GNAQ, KRAS, KRT14, KRT16, PLK1, PTHLH, SH3PXD2A |
Transmigration of myeloid cells | 7.13E-02 | 2.0 | CXCL5, CXCL8, ITGAV, LGALS1 |
Transmigration of phagocytes | 9.78E-02 | 2.0 | CXCL5, CXCL8, ITGAV, LGALS1 |
Cell cycle progression | 7.13E-02 | 2.2 | BIRC5, CDC25B, CKAP2, FOS, KRAS, LGALS4, MAP3K1, PLK1, XIAP |