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Fig. 4 | BMC Genomics

Fig. 4

From: Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis

Fig. 4

Visualization of association networks revealed by eGWAS (a, b) and links with ASE (c). Association networks were constructed based on multiple associations between eQTL-SNPs or genes, and were visualized by Cytoscapev3.2.1. eQTL-SNPs and genes are represented by red and blue dots, respectively. Associations are depicted with directed edges (oriented arrows) to show regulation by the eQTL-SNP genotype on gene transcription and not the reverse. Local associations are drawn with red arrows and distant associations with blue dotted arrows. All nodes correspond either to a gene or an eQTL-SNP, with the names indicated. Names in bold are further described in the results. a: The biggest association network drawn in this study comprises 154 nodes (eQTL-SNPs or genes). It is centered on two eQTL-SNPs: H3GA0029721 (rs81422644), which was distant-associated with 51 probes representing 47 genes, and ALGA0034786 (rs81393122). b: Visualization of the association networks centered on eQTL-SNPs MARC0001946, ALGA0110383, and MARC0056482. c: Map of a segment of SSC6 that comprises the ASE-SNP rs242721226 and the eQTL-SNPs ALGA0110383 and MARC0056482. The distances between the position of ASE-SNP rs342721226 and the eQTL-SNPs ALGA0110383 and MARC0056482 are 676 and 381 Kb, respectively

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BMC Genomics

ISSN: 1471-2164

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