Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation

Witt, Stephanie H.; Frank, Josef; Gilles, Maria; Lang, Maren; Treutlein, Jens; Streit, Fabian; Wolf, Isabell A. C.; Peus, Verena; Scharnholz, Barbara; Send, Tabea S.; Heilmann-Heimbach, Stefanie; Sivalingam, Sugirthan; Dukal, Helene; Strohmaier, Jana; Sütterlin, Marc; Arloth, Janine; Laucht, Manfred; Nöthen, Markus M.; Deuschle, Michael; Rietschel, Marcella

doi:10.1186/s12864-018-4652-7

BMC Genomics

Table 3 Results of mediation analysis

From: Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation

Name	ACME^a	P_ACME	ADE^b	P_ADE	Total^c	P_total	P_meth(nik)^d	P_nik(meth)^e	P_nik^f
cg04865726	- 19.1	0.363	- 189	0.031	- 208	0.014	0.367	0.033	0.023
cg09662411	4.6	0.864	- 213	0.016	- 208	0.016	0.860	0.019	0.023
cg06338710	- 5.6	0.797	- 203	0.027	- 208	0.017	0.802	0.023	0.023
cg18146737	- 30.6	0.252	- 177	0.048	- 208	0.016	0.241	0.049	0.023
cg12876356	- 36.4	0.154	- 172	0.057	- 208	0.014	0.165	0.055	0.023
cg18316974	- 31.4	0.248	- 176	0.053	- 207	0.017	0.248	0.049	0.023
cg09935388	- 46.0	0.149	- 160	0.078	- 206	0.018	0.148	0.077	0.023
cg14179389	- 53.8	0.061	- 154	0.085	- 208	0.015	0.065	0.087	0.023
cg11641006	13.6	0.559	- 221	0.014	- 207	0.017	0.565	0.013	0.023
cg23067299	23.8	0.254	- 232	0.008	- 209	0.012	0.246	0.009	0.023
cg23916896	8.4	0.663	- 217	0.010	- 209	0.012	0.661	0.014	0.023
cg11902777	4.0	0.856	- 211	0.015	- 207	0.013	0.848	0.017	0.023
cg05575921	- 38.0	0.400	- 171	0.077	- 209	0.015	0.386	0.080	0.023
cg21161138	- 2.0	0.928	- 206	0.019	- 208	0.015	0.927	0.021	0.023
cg25325512	- 56.3	0.005	- 152	0.082	- 209	0.017	0.005	0.081	0.023
cg23594693	- 6.2	0.767	- 200	0.023	- 207	0.017	0.763	0.023	0.023
cg02227813	- 22.9	0.275	- 186	0.035	- 209	0.015	0.276	0.036	0.023
cg07249149	- 19.7	0.323	- 189	0.030	- 209	0.014	0.332	0.032	0.023
cg19089201	- 15.7	0.495	- 191	0.031	- 207	0.016	0.500	0.031	0.023
cg22132788	- 5.7	0.766	- 202	0.023	- 208	0.015	0.772	0.022	0.023
cg04180046	- 14.0	0.606	- 193	0.031	- 207	0.017	0.604	0.031	0.023
cg12803068	6.3	0.785	- 214	0.014	- 208	0.015	0.774	0.016	0.023
cg25949550	75.7	0.008	- 283	0.002	- 208	0.017	0.009	0.002	0.023
cg15578140	- 14.7	0.530	- 194	0.029	- 209	0.012	0.523	0.031	0.023
cg11813497	18.5	0.353	- 227	0.009	- 208	0.016	0.366	0.010	0.023
cg26033520	29.7	0.123	- 239	0.008	- 210	0.015	0.121	0.007	0.023
cg08699196	- 39.6	0.045	- 169	0.051	- 208	0.013	0.043	0.055	0.023
cg05549655	1.1	0.956	- 209	0.017	- 208	0.016	0.967	0.019	0.023
cg13859324	- 18.4	0.401	- 190	0.029	- 209	0.012	0.401	0.033	0.023
cg11043990	- 28.7	0.173	- 177	0.042	- 206	0.017	0.169	0.042	0.023

^aAverage causal mediation effect in g
^bAverage direct effect in g
^cTotal effect of smoking on birth weight (ACME+ADE)
^dAssociation between birth weight and methylation after adjustment for smoking and covariates
^eAssociation between birth weight and sustained maternal smoking after adjustment for methylation and covariates
^fAssociation between maternal smoking and birth weight after adjustment for covariates, irrespective of methylation levels

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ISSN: 1471-2164

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