Table 3 The greatest functional classification differences between CK and LS
NO | Pathway | DEGs genes (119) / All genes (28890) with pathway annotation | P value | Pathway ID |
|---|---|---|---|---|
1 | Proximal tubule bicarbonate reclamation | 4 (4.2%) / 53 (0.18%) | 1.239607e-05 | ko04964 |
2 | Fructose and mannose metabolism | 5 (4.2%) / 98 (0.34%) | 0.000239203 | ko00051 |
3 | Protein digestion and absorption | 10 (8.4%) / 456 (1.58%) | 0.000280083 | ko04974 |
4 | Bile secretion | 7 (5.9%) / 226 (0.78%) | 0.0003098698 | ko04976 |
5 | Amoebiasis | 17 (14.3%) / 1195 (4.14%) | 0.0004429313 | ko05146 |
6 | Antigen processing and presentation | 5 (4.2%) / 113 (0.39%) | 0.0004620034 | ko04612 |
7 | Protein processing in endoplasmic reticulum | 9 (7.6%) / 455 (1.57%) | 0.001166426 | ko04141 |
8 | Glycosphingolipid biosynthesis - lacto and neolacto series | 4 (3.4%) / 94 (0.33%) | 0.002007803 | ko00601 |
9 | Thyroid hormone signaling pathway | 11 (9.2%) / 746 (2.58%) | 0.003509184 | ko04919 |
10 | AMPK signaling pathway | 8 (6.7%) / 465 (1.61%) | 0.005048467 | ko04152 |
11 | Nitrogen metabolism | 2 (1.7%) / 19 (0.07%) | 0.005079646 | ko00910 |
12 | Vibrio cholerae infection | 14 (11.8%) / 1170 (4.05%) | 0.006652947 | ko05110 |
13 | Mineral absorption | 5 (4.2%) / 214 (0.74%) | 0.007464861 | ko04978 |
14 | Adipocytokine signaling pathway | 4 (3.4%) / 153 (0.53%) | 0.01119608 | ko04920 |
15 | ECM-receptor interaction | 7 (5.9%) / 440 (1.52%) | 0.01272333 | ko04512 |
16 | Toxoplasmosis | 4 (3.4%) / 172 (0.6%) | 0.01655378 | ko05145 |
17 | Insulin secretion | 5 (4.2%) / 264 (0.91%) | 0.01723485 | ko04911 |
18 | Thyroid hormone synthesis | 4 (3.4%) / 195 (0.67%) | 0.02489002 | ko04918 |
19 | PI3K-Akt signaling pathway | 14 (11.8%) / 1386 (4.8%) | 0.0255091 | ko04151 |
20 | Insulin resistance | 4 (3.4%) /214 (0.74%) | 0.0333897 | ko04931 |