Fig. 8

Allele-specific transcription, H3K27ac and DNA methylation at the MIR4458HG locus. a Integration of allele-specific gene expression and promoter H3K27ac enrichment using human brain RNA-seq and matched ChIP-seq datasets. Only transcripts with informative allele-specific RNA-seq coverage over exons and ChIP-seq coverage over TSSs (+/− 300 bp) are shown (n = 1759). b Distribution of H3K27ac and input/control allelic ratios at TSSs of transcripts expressed from one or both alleles. Note the allelic ratio bias even in the input control. c UCSC genome browser screenshot of the MIR4458HG locus. Only the expressed allele (hap2) is enriched for H3K27ac and hypomethylated at the CpG island promoter