Fig. 4
From: Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data
Differential splicing and isoform switching of kinase gene CDK5 in prostate cancer. a The transcript structure of CDK5. CDK5 is located on Chromosome 7 and has two annotated isoforms: NM_004935 (Isoform1) and NM_001164410 (Isoform2). Isoform1 has 12 exons, and its 6th exon is skipped in Isoform2. b Differential splicing of CDK5 illustrated by DEXSeq [17]. The relative exon usage, as measured by “fitted splicing”, was plotted for each exon in two groups. Blue lines are for prostate benign samples and red lines are for prostate cancer samples. The panel at the bottom shows the location of the exons, with the alternative exon highlighted in red. c Expression boxplots of the two isoforms in prostate cancer and benign tissue samples. d Expression boxplots of the two isoforms in the androgen-independent and androgen-dependent prostate cancer cell lines