Table 1 Top 10 up-regulated and down-regulated genes in prostate cancer samples
From: Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data
Gene Symbol | log2(Fold-change) | p-value | Role in prostate cancer based on literature and database search |
|---|---|---|---|
Top 10 up-regulated genes | |||
 PLA2G2A | 2.3884419 | 0 | An enzyme in inflammatory process, might serve as a prognostic marker |
 ORM1 | 3.9940791 | 0 | AR-activated gene and involved in AR pathway |
 TARP | 2.0779529 | 3.13E-196 | Prostate-specific protein and leads to increased growth rate of prostate cancer cells |
 ORM2 | 3.0434879 | 1.52E-157 |  |
 PCA3 | 4.0035279 | 1.26E-132 | Highly expressed in prostate cancer tissue, a genetic marker for prostate cancer diagnosis |
 SPON2 | 2.0706815 | 9.75E-121 | Over expressed in prostate cancer tissues, could be used as a biomarker |
 HPN | 2.4321643 | 5.79E-49 | Involved in maintenance of cell morphology and growth of various cancer types, correlates with progression of prostate cancer and promotes cancer progression and metastasis |
 STEAP4 | 1.9395011 | 4.48E-44 | Module metastasis and invasion of cancer cells through regulating focal adhesion kinase activation |
 MCCC2 | 2.0394019 | 4.89E-41 | AR-regulated gene and strongly up-regulated in primary prostate cancer |
 PDLIM5 | 1.8980125 | 2.39E-40 |  |
Top 10 down-regulated genes | |||
 SERPINA3 | −1.496602 | 0 | Associated with increased risk of prostate cancer |
 LTF | −1.576865 | 0 | Plays roles in several important biological processes such as cellular growth, inflammatory response, cancer development and metastasis |
 SAA1 | −4.021895 | 0 |  |
 LCN2 | −2.156207 | 0 |  |
 SOD2 | −0.886676 | 1.82E-268 | A tumor suppressor gene, the suppression of prostate cancer cell growth by mediating the senescence-associated tumor suppression |
 CFB | −1.251122 | 5.91E-225 |  |
 MT2A | −0.516269 | 2.57E-188 | Interact with kinase domain of protein kinase Cmu(PKCmu) in prostate cancer |
 OLFM4 | −1.481793 | 6.63E-188 | Inhibit prostate cancer growth and metastasis with nteraction of cathepsin D and SDF-1 |
 PSCA | −0.367134 | 1.70E-186 |  |
 S100A9 | −2.169907 | 8.63E-143 |  |