Fig. 10

The top panel (a) depicts another gene interaction network identified by IPA in the E18 vs. D3 contrast. This gene network, functionally annotated by IPA as “Cell Signaling”, shows interactions of eight transcription factors (NFYC, THRSP, KAT2B, KLF13, EAF1, EAF2, SOX7 and SOX8) and their direct target genes. The second gene network (b) was functionally annotated by IPA as “Hematological System Development and Function”. This network of genes, which are highly expressed in liver of E18 embryos, involves interactions among six blood clotting factors [F5, F8, F9, F11, PROS1 and von Willebrand factor (VWF)] with macrophage stimulating 1 (MST1), the chromatin remodeling gene [helicase lymphoid specific (HELLS)], a mitochondrial chaperone [heat shock protein family D (Hsp60) member 1 (HSPD1)], SRY-box 7 (SOX7), several collagen genes (COL1A1, COL3A1 and COL18A1), fibulin 1–2 (FBLN1, FIBLN2) and components of the extracellular matrix [secreted protein acidic and cysteine rich (SPARC), laminin subunit beta-1, − 3 (LAMB1, LAMB3) and lysyl oxidase (LOX)]