Table 2 Interpretations of biological components
From: Thirty biologically interpretable clusters of transcription factors distinguish cancer type
Cl. | ToppGene | Lethal | Top five | UniGene tissues |
|---|---|---|---|---|
1 | Cell cycle; chromosome organization | Yes | LAML; ESCA; TGCT; LUSC; READ | More than four |
2 | Lipid metabolism; liver; cytochrome p450 | No | LIHC; CHOL; STAD; COAD; READ | Brain; intestine; liver |
3 | Extracellular matrix; angiogenesis | No | UCEC; OV; UCS; SARC; PCPG | More than four |
4 | Synaptic signaling; neuron; synapse; | No | LGG; GBM; PCPG; TGCT; UVM | Brain |
5 | Cell cycle; condensed chromosome | Yes | UCS; CESC; DLBC; THYM; UCEC | More than four |
6 | Transcription factor activity; mitochondria | No | UVM; LAML; ESCA; LGG; STAD | More than four |
7 | Cell cycle | Yes | TGCT; UCS; OV; ESCA; READ | More than four |
8 | Mitochondrial; post-synapse; guanyl-nucleotide activity; lung; breast; ovary; testis | No | LGG; KIRC; SARC; LAML; GBM | Brain; lung; testis |
9 | Neuropeptide; synaptic signaling; abnormal pterygopalatine ganglion morphology | No | PCPG; PAAD; TGCT; READ; UCS | Brain |
10 | Transcription factor activity; centrosome; microtubule | No | LGG; GBM; UCS; TGCT; THYM | Brain; embryonic tissue; testis |
11 | Apoptosis; gametogenesis | No | LAML; OV; TGCT; UCS; UCEC | Brain; kidney; testis |
12 | Microtubule; centriole; stem cell | No | UVM; THYM; UCS; LGG; UCEC | Lung; prostate; uterus |
13 | Cytokine receptor activity; immune response; lymphadenopathy | No | DLBC; STAD; LAML; PAAD; ESCA | Intestine; lung; uterus |
14 | Regionalization; vertebral transformation; leukemia | No | KICH; KIRP; UCS; KIRC; PCPG | Kidney; uterus |
15 | Collagen; thyroid; thyroid hormone synthesis | No | THCA; LUAD; LUSC; KIRP; OV | Brain; lung; prostate; uterus |
16 | Muscle | No | UCS; HNSC; TGCT; OV; SARC | Muscle |
17 | Melanin; melanosome | No | UVM; SKCM; GBM; TGCT; LGG | Embryonic tissue |
18 | Epithelium development; abnormal digestive system development; keratinization | No | PRAD; BRCA; LUAD; LUSC; BLCA | Lung |
19 | Extracellular matrix; epithelium development; collagens; keratins | No | HNSC; UCS; CESC; ESCA; LUSC | Eye; lung; skin; uterus |
20 | Eye lens; reproduction; gametogenesis; pluripotent stem cells; TGCT | Yes | TGCT; ACC; THYM; OV; LAML | Embryonic tissue; testis |
21 | Cytoskeleton; tubulin binding; cell cycle; neuron; | Yes | LGG; GBM; PRAD; KIRC; KICH | Brain; eye; testis |
22 | Pol II; uveitis; abnormla myeloid cell morphology; ovary; trachea; lung | No | HNSC; ESCA; PAAD; STAD; CESC | More than four |
23 | NADH dehydrogenase activity; oxidative phosphorylation; respiratory electron transport; | Yes | ACC; THYM; PCPG; UVM; THCA | More than four |
24 | NADH dehydrogenase activity; oxidative phosphorylation; developing kidney | Yes | LAML; ESCA; STAD; BRCA; OV | More than four |
25 | Immune response; leukocyte activation; | No | DLBC; LAML; STAD; THYM; LUAD | Blood; brain; lung; lymph node |
26 | Fatty acid binding; dogestion; microvillus; intestinal epithelium | No | COAD; READ; STAD; PAAD; ESCA | Intestine |
27 | Structural constituent of ribosome; endoplasmic reticulum; eukaryotic translation | Yes | DLBC; THYM; UCS; UCEC; TGCT | More than four |
28 | CNS development; growth cone; forebrain; | No | GBM; LGG; UCS; CESC; HNSC | Brain |
29 | Growth factor binding; angiogenesis; focal adhesion; | Yes | ESCA; HNSC; GBM; LUSC; KIRC | Brain; embryonic tissue; lung |
30 | Cell-cell adhesion; cell-cell junction; digestive system; claudins | No | STAD; READ; COAD; PAAD; BLCA | Lung; pancreas |