Table 1 Biological functions of the identified 44 essential genes

let-609

let-363

h191

C- > T

R- > X

Phosphatidylinositol 3- and 4-kinase

Replication, recombination and repair

I,F,M,N

let-643

nath-10

h500

G- > A

R- > K

GNAT acetyltransferase 2

General function prediction only

I,F,M,N

let-624/ let-644/ let-622

npp-6

h449,h839,h222

C- > T

Q- > X

Nucleoporin Nup120/160

Unkown

I,F,M,N

let-610

asd-2

h695

C- > T

P- > S

Homodimerisation region of STAR domain protein

RNA processing and modification

I,F,M,N

let-639/ let-371

hcp-6

h779,h123

G- > A

W- > X

non-SMC mitotic condensation complex subunit 1

Function unknown

I,F,M,N

let-138/ let-150/ let-357

spg-7

h744,h282,h89

G- > A

W- > X

Peptidase family M41

Posttranslational modification, protein turnover, chaperones

I,F,M,N

let-163

sep-1

h483

C- > T

Q- > X

Peptidase family C50

Cell cycle control, cell division. Chromosome partitioning

F,M,N

let-133

Y71G12B.8

h440

T- > A

Y- > X

DEAD/DEAH box helicase

RNA processing and modification

I,F,M,N

let-593

inx-13

h212

C- > T

Q- > X

Innexin

Unkown

I,F,N

let-625

rpl-4

h506

G- > A

D- > N

Ribosomal protein L4/L1 family

RNA processing and modification

I,F,M,N

let-633/ let-638

B0261.1

h696,h778

C- > T

R- > X

Myb DNA-binding like

Transcription

I,F,M,N

let-648

vha-16

h781

G- > A

D- > N

Unkown

Unkown

I,N,M,F

let-615

rpl-13

h529

C- > T

Q- > X

Ribosomal protein L13e

Translation, ribosomal structure and biogenesis

I,F,M,N

let-356

cdc-6

h501

G- > A

G- > R

ATPase family associated with various cellular activities (AAA)

Cell cycle control, cell division. Chromosome partitioning;Replication, recombination and repair

I,F,M,N

let-505

tufm-2

h426

C- > T

R- > X

Elongation factor Tu GTP binding domain

Translation, ribosomal structure and biogenesis

I,F,M,N

let-128

C53H9.2

h253

465 + 1G > A

None

50S ribosome-binding GTPase

General function prediction only

I,F,M,N

let-398

gpc-2

h257

C- > T

Q- > X

GGL domain

Signal transduction mechanisms

I,F,M,N

let-619/ let-105

dip-2

h348,h681

C- > T

H- > Y

AMP-binding enzyme

General function prediction only

I,F,M,N

let-649/ let-109

him-1

h491,h811

G- > A

G- > R

RecF/RecN/SMC N terminal domain

Cell cycle control, cell division. Chromosome partitioning

I,N,M,F

let-578

npp-11

h512

G- > A

W- > X

Nucleoporin FG repeat region

Intracellular trafficking, secretion, and vesicular transport;Nuclear structure

I,F,M,N

let-543/ let-544

sacy-1

h792,h692

G- > A

G- > R

DEAD/DEAH box helicase

RNA processing and modification

I,F,M,N

let-614

rmh-1

h147

C- > T

S- > L

RecQ mediated genome instability protein

Function unknown

F,N

let-582

egg-4

h726

G- > A

A- > T

Protein-tyrosine phosphatase

Signal transduction mechanisms

I,F,M,N

let-528

cytb-5.2

h1012

G- > A

W- > X

Cytochrome b5-like Heme/Steroid binding domain

Energy production and conversion

I,F,M,N

let-511

W09C3.4

h755

262-1G > A

None

RNA polymerase Rpc34 subunit

Transcription

I,F,M,N

let-135

pop-1

h268

G- > A

A- > T

HMG (high mobility group) box

Transcription

I,F,M,N

let-502

spe-5

h767

C- > T

S- > F

ATP synthase alpha/beta family, nucleotide-binding domain

Energy production and conversion

I,F,M,N

let-143

npp-13

h513

G- > A

G- > E

Nup93/Nic96

Cell cycle control, cell division. Chromosome partitioning

I,F,M,N

let-571

eif-2gamma

h347

G- > A

G- > R

Initiation factor eIF2 gamma, C terminal

Translation, ribosomal structure and biogenesis

I,F,M,N

let-155

inx-21

h461

C- > T

R- > X

Innexin

Unkown

I,F,N

let-162

Y47G6A.18

h460

G- > A

G- > E

Golgi phosphoprotein 3 (GPP34)

Intracellular trafficking, secretion, and vesicular transport

I,F,M,N

let-510

Y47G6A.19

h740

1355-1G > A

None

Zinc carboxypeptidase

Function unknown

I,F,M,N

let-357

lpd-3

h132

1539 + 1G > A

None

Fragile site-associated protein C-terminus

Unkown

I,F,M,N

let-546

xpo-2

h227

G- > A

W- > X

Cse1

Intracellular trafficking, secretion, and vesicular transport;Nuclear structure

I,F,M,N

let-121/ let-146

cdt-1

h810,h197

C- > T

Q- > X

DNA replication factor CDT1 like

Unkown

I,F,M,N

let-130

lpr-1

h773

G- > A

R- > Q

Unkown

Unkown

F,N

let-573

rpl-1

h247

C- > T

T- > I

Ribosomal protein L1p/L10e family

Translation, ribosomal structure and biogenesis

I,F,M,N

let-145

arx-1

h182

C- > T

Q- > X

Actin

Cytoskeleton

I,F,M,N

let-123/ let-142/ let-583

cogc-3

h413,h518,h738

G- > A

G- > R

Sec34-like family

Intracellular trafficking, secretion, and vesicular transport

I,F,M,N

let-577

sop-3

h503

G- > A

E- > K

Unkown

Unkown

F,M,N

let-548/ let-144

tln-1

h356,h393

C- > T

Q- > X

Talin, middle domain

Cytoskeleton

I,F,M,N

let-131

Y71G12B.6

h817

C- > T

Q- > X

GDP-mannose 4,6 dehydratase

Unkown

F,N

let-392

nekl-2

h120,h122

G- > A

G- > E

Protein kinase domain

General function prediction only

F,M,N

let-374

lpd-5

h251

G- > A

W- > X

Unkown

Unkown

I,F,M,N