Fig. 2

Consistency and reproducibility of APP co-splicing in hippocampus. a Correlation between transcriptome-wide APP co-expression and co-splicing correlations. Each point is a gene for which its co-expression and co-splicing correlations (z-transformed) with APP were computed. A high correlation was found for hippocampus data of GTEx, where high co-splicing is a clear subset of high co-expression: {genes such that z co-splicing > 1} ⊂ {genes such that z co-expression > 1}, where z = 1 corresponds to a correlation of 0.76. b Reproducibility between independent studies. Mantel co-splicing correlations (z-transformed) with APP was computed in two independent studies (GTEx and BRAINEAC). While the correlation is moderate, it is highly significant, showing that genes with high APP co-splicing in GTEx are also likely to be high in APP co-splicing in BRAINEAC. Co-splicing correlations in GTEx are higher than in BRAINEAC