A unique insight into the MiRNA profile during genital chlamydial infection

Benyeogor, Ifeyinwa; Simoneaux, Tankya; Wu, Yuehao; Lundy, Stephanie; George, Zenas; Ryans, Khamia; McKeithen, Danielle; Pais, Roshan; Ellerson, Debra; Lorenz, W. Walter; Omosun, Tolulope; Thompson, Winston; Eko, Francis O.; Black, Carolyn M.; Blas-Machado, Uriel; Igietseme, Joseph U.; He, Qing; Omosun, Yusuf

doi:10.1186/s12864-019-5495-6

BMC Genomics

Table 3 Differentially expressed miRNAs after Chlamydia reinfections

From: A unique insight into the MiRNA profile during genital chlamydial infection

Week	miR	Fold Change(Log)	P value*	Direction
Week 1	mmu-miR-378b^a	3.19	0.0000009	UP
	mmu-miR-3968^c	−1.75	0.000042	DOWN
	mmu-miR-106a-5p^a	1.86	0.000091	UP
	mmu-miR-423-5p^a	−1.52	0.00016	DOWN
	mmu-miR-92a-3p^a	−1.70	0.00022	DOWN
	mmu-miR-199a-5p^a	1.78	0.000257	UP
	mmu-miR-127-3p^a	−1.35	0.000332	DOWN
	mmu-miR-17-5p^a	1.20	0.000495	UP
	mmu-miR-340-5p^a	−1.26	0.000698	DOWN
	mmu-miR-195a-3p^b	1.25	0.001594	UP
	mmu-miR-322-5p ^c	1.30	0.00161	UP
	mmu-miR-199b-5p^a	1.47	0.001765	UP
Week 2	mmu-miR-205-5p^a	−5.14	0.0000000	DOWN
	mmu-miR-342-5p^a	−3.18	0.0000000	DOWN
	mmu-miR-147-3p^b	−3.29	0.0000000	DOWN
	mmu-miR-135b-5p^a	−2.06	0.0000000	DOWN
	mmu-miR-363-3p^a	−2.55	0.000001	DOWN
	mmu-miR-142-3p^a	−2.46	0.000001	DOWN
	mmu-miR-145a-5p^b	2.03	0.000005	UP
	mmu-miR-142-5p^a	−1.81	0.000012	DOWN
	mmu-miR-129-2-3p^a	1.74	0.000013	UP
	mmu-miR-187-3p^a	1.50	0.000039	UP
	mmu-miR-451a^a	1.43	0.000105	UP
	mmu-miR-31–3p^a	2.07	0.00013	UP
	mmu-miR-326-3p^a	1.48	0.000185	UP
	mmu-miR-204-5p^a	1.41	0.000188	UP
	mmu-miR-532-3p^a	1.54	0.000195	UP
	mmu-miR-146b-5p^b	−1.34	0.000219	DOWN
	mmu-miR-146a-5p^a	−1.74	0.000231	DOWN
	mmu-miR-20b-5p^a	−1.73	0.000402	DOWN
	mmu-miR-151-5p^b	1.24	0.000438	UP
	mmu-miR-335-3p^a	−1.96	0.000541	DOWN
	mmu-miR-212-5p^a	−1.18	0.000733	DOWN
	mmu-miR-31-5p^b	1.45	0.000829	UP
	mmu-miR-130b-5p^a	−1.25	0.000892	DOWN
	mmu-let-7d-3p^a	−1.32	0.001096	DOWN
	mmu-let-7b-3p^a	−1.46	0.001203	DOWN
	mmu-miR-378b^a	1.77	0.001282	UP
	mmu-miR-350-5p ^c	−1.33	0.00141	DOWN
	mmu-miR-1198-5p ^c	−1.28	0.001676	DOWN
	mmu-let-7j^b	−1.24	0.00175	DOWN
	mmu-miR-222-3p^a	−1.01	0.001753	DOWN
	mmu-miR-574-5p^a	−1.64	0.001819	DOWN
	mmu-miR-128-3p^b	−1.05	0.00218	DOWN
	mmu-let-7a-1-3p^a	−1.06	0.002268	DOWN
	mmu-let-7c-2-3p^a	−1.06	0.002284	DOWN
	mmu-miR-203-3p^b	−0.98	0.003381	DOWN
	mmu-miR-1291^a	−1.11	0.00341	DOWN
	mmu-miR-10a-5p^a	0.96	0.003667	UP
	mmu-miR-338-5p^a	−1.14	0.004249	DOWN
	mmu-miR-223-5p^a	−1.22	0.004819	DOWN
	mmu-miR-193a-5p^a	−1.10	0.005228	DOWN
	mmu-miR-494-3p^a	1.04	0.005263	UP
	mmu-miR-296-3p^a	−1.16	0.005263	DOWN
Week 4	mmu-miR-142-3p^a	−2.17	0.0000000	DOWN
	mmu-miR-106a-5p^a	−1.77	0.000001	DOWN
	mmu-miR-142-5p^a	−1.42	0.000048	DOWN
	mmu-miR-339-5p^a	−1.20	0.000052	DOWN
	mmu-miR-20b-5p^a	−1.42	0.000055	DOWN
	mmu-miR-146a-5p^a	−1.49	0.000209	DOWN
	mmu-miR-511–3p^a	−1.38	0.000261	DOWN
	mmu-miR-16-2-3p^a	−1.34	0.000433	DOWN
	mmu-miR-15a-5p^a	−1.07	0.000485	DOWN
	mmu-miR-497-3p^a	−1.20	0.001221	DOWN
Week 8	mmu-miR-378b^a	−3.84	0.000081	DOWN

miRNAs expressed weeks 1, 2, 4 and 8 after infection; ^a miRNAs that have an exact human homolog in miRBase; ^b miRNAs that do not have an exact human homolog in miRBase, but might be different by a few nucleotides, ^c no known human homolog in miRBase. *P-value significance threshold was set at p < 0.05. p-values here were adjusted or controlled by false discovery rate. Positive fold change (log) value indicates upregulation of the expressed miRNA while a negative fold change (log) value indicates downregulation of the expressed miRNAs

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ISSN: 1471-2164

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