Fig. 8

Electrostatic surface potential of the chIFITM3 model. The surface of chIFITM3 is colored according to the Coulombic surface charge of surface accessible residues. The structured segment of the model features a polar (negatively charged) C-terminal cap, a non-polar transmembrane segment and two amphipathic helices on the intracellular face of the membrane. The unstructured N-terminal segment is heavily charged, as expected from a solvent-exposed intrinsically disordered region