Table 4 Upstream regulators identified by IPA comparing lactate with NaCl vehicle control treated GC
Upstream Regulator | Predicted Activation State | Activation z-score | p-value of overlap |
|---|---|---|---|
TNF | Activated | 3.784 | 2.27E-29 |
dexamethasone | 0 | 5.65E-26 | |
beta-estradiol | Activated | 2.682 | 4.18E-25 |
Cg | Activated | 3.524 | 7.12E-24 |
IL1B | Activated | 2.977 | 1.68E-23 |
ESR2 | 1.642 | 8.62E-23 | |
forskolin | Activated | 2.959 | 3.19E-22 |
progesterone | Activated | 2.292 | 1.06E-21 |
tretinoin | Activated | 2.311 | 1.46E-21 |
Vegf | Activated | 4.187 | 1.71E-21 |