Fig. 6
From: Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Comparison of tests of linear regression assumptions with bias in DNA methylation association studies. Scatterplots of –log10(p-value) (y-axis) from the (a) global (b) skewness (c) kurtosis (d) link function and (e) heteroskedasticity tests performed in the R gvlma package against average (mean) ranking from 1000 simulated null association studies (x-axis) for all DNA methylation sites. Each point represents a single site, and the color represents the density of points plotted at that position (low density in grey to high density in yellow)