Skip to main content

Table 3 Variants identified in MGIT and sputum derived sequences from paired samples

From: Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture

 

Sputum variants

MGIT variants

Total variants

24,480

25,465

Total variants present as HAs (% of total variants)

265 (1.1%)

200 (0.8%)

Median HAs per sample

5.0

4.5

Variant type (% all HAs)

 SNP

217 (81.9%)

174 (87.0%)

 MNP

2 (0.8%)

0 (0.0%)

 Insertion

4 (1.5%)

1 (0.5%)

 Deletion

24 (9.1%)

15 (7.5%)

 Complex

18 (6.8%)

10 (5.0%)

Coding change (% all HAs)

 Non-synonymous (missense)

93 (35.1%)

77 (38.5%)

 Non-synonymous (frameshift)

6 (2.3%)

7 (3.5%)

 Synonymous

57 (21.5%)

57 (28.5%)

 Intergenic

109 (41.1%)

59 (29.5%)

  1. Values given represent totals for 32 paired samples. SNP single nucleotide polymorphism, MNP multi-nucleotide polymorphism