From: Analysis of the equine “cumulome” reveals major metabolic aberrations after maturation in vitro
Metabolic Groups with their Proteins/Metabolites | Abbreviation Figure | Proteomics: Orthologous Human Accession Uniprot | Proteomics: NCBI Accession | Anova (Progenesis) | Max fold change (Progenesis) | Up/Down in-vitro |
---|---|---|---|---|---|---|
Metabolomics: HMDB ID | Metabolomics: Compound (m/z) | |||||
1 Oxygen Supply (proteins: n = 5; metabolites n = 2) | ||||||
Hemoglobin A | HBA | HBA_HUMAN | NP_001078901.1 | 0.015 | 25.58 | Down |
Hemoglobin B | HBB | HBB_HUMAN | NP_001157490.1;XP_001504241.1 | 0.007 | 52.65 | Down |
Ceruloplasmin | CP | CERU_HUMAN | XP_001491539.1;XP_014587394.1;XP_014587022.1 | < 0.001 | 140.94 | Down |
Transferrin | TF | TRFE_HUMAN | NP_001075415.2 | 0.003 | 10.25 | Down |
Hemopexin | HEMO | HEMO_HUMAN | XP_005612174.1 | 0.010 | 10.14 | Down |
Hydroxymethylbilane | Hydroxymethylbilane | HMDB01137 | 4.89_426.1165 m/z | 0.001 | 16.86 | Down |
Bilirubin-Glucuronide | Bilirubin-Gluc | HMDB10332 | 6.37_741.2851 m/z | 0.040 | 2.21 | Up |
2 Glucose Metabolism (proteins n = 4; metabolites n = 5) | ||||||
Glutamine-fructose-6-phosphate aminotransferase 1 | GFPT1 | GFPT1_HUMAN | XP_005599972.1 | < 0.001 | 101.18 | Down |
Glutamine-fructose-6-phosphate aminotransferase 2 | GFPT2 | GFPT2_HUMAN | XP_014585826.1 | 0.024 | 2.80 | Down |
ATP dependend 6-phosphofructokinase muscle type | PFK-M | PFKAM_HUMAN | XP_005611133.1;XP_014596234.1 | 0.006 | 4.67 | Up |
Solute Carrier Family 2, facilitated glucose transporter member 1 | GLUT1 | GTR1_HUMAN | NP_001157443.1;XP_005607060.1 | 0.040 | 2.01 | Down |
Phosphoenolpyruvate | PEP | HMDB00263 | 6.23_166.9749 m/z | 0.018 | 157.36 | Up |
D-Lactate / L-Lactate | Lactate | HMDB00190 | 6.41_111.0085 m/z | 0.019 | 2.78 | Up |
Hexose-Monophosphate | Hexose-P | not specified | 6.41_259.0217 m/z | 0.039 | 6.10 | Up |
Citrate/Isocitrate | Citrate | HMDB00094 | 6.84_191.0191 m/z | 0.024 | 4.04 | Up |
2-phospho-d-glyceric acid | 2PG | HMDB03391 | 6.39_185.9927n | 0.026 | 10.30 | Up |
3 Fatty Acid Metabolism (proteins n = 9; metabolites n = 3) | ||||||
Apolipoprotein A1 | APOA1 | APOA1_HUMAN | XP_005611649.1 | 0.001 | 30.68 | Down |
Apolipoprotein A2 | APOA2 | APOA2_HUMAN | XP_001503846.1 | 0.003 | 48.44 | Down |
Apolipoprotein H | APOH | APOH_HUMAN | XP_001499728.1 | < 0.001 | 30.74 | Down |
Adiponectin | ADIPO | ADIPO_HUMAN | XP_001499564.1 | 0.009 | 8.64 | Down |
Acetyl-CoA carboxylase 1 | ACACA | ACACA_HUMAN | XP_005597614.1;XP_001496980.1 | < 0.001 | 6.07 | Up |
Fatty acid synthase | FASN | FAS_HUMAN | XP_014591306.1 | 0.001 | 2.64 | Up |
Long-chain-fatty-acid-CoA ligase 3 | ACSL | ACSL3_HUMAN | XP_001915556.1 | 0.013 | 4.14 | Up |
Fatty acid binding protein | FABP | FABPH_HUMAN | NP_001157357.1;XP_005607059.1 | 0.001 | 46.96 | Up |
Acyl-CoA desaturase | ACOD | ACOD_HUMAN | XP_001500414.1 | < 0.001 | 7.97 | Up |
O-Phosphoethanolamine | O-Phosphoethanolamine | HMDB00224 | 4.64_175.9943 m/z | 0.002 | 2.76 | Up |
Diacyglycerol (40:7) | DAG (40:7) | not specified | 3.61_647.5261 m/z | 0.024 | 11.18 | Up |
CDP-Ethanolamine | CDP-Ethanolamine | HMDB01564 | 4.85_222.0249 m/z | 0.021 | 2.75 | Up |
4 Oxidative Phosporylation (proteins n = 1; metabolites n = 1) | ||||||
NADH-ubiquinone oxidoreductase chain 5 | Mt-ND5 | NU5M_HUMAN | NP_007170.1 | 0.046 | 3.61 | Up |
reduced flavin mononucleotide | FMNH2 | HMDB01142 | 7.19_439.0852 m/z | < 0.001 | 4.37 | Up |
5 Amino Acid Metabolism (proteins n = 7; metabolites n = 4) | ||||||
phosphoserine aminotransferase | PSAT1 | SERC_HUMAN | XP_001496412.1 | 0.022 | 9.40 | Up |
L-Serine; D-Serine | SERINE | HMDB00187; HMDB03406 | 4.98_104.0352 m/z | 0.008 | 3.22 | Down |
Phosphohydroxypyruvic acid | PHPA | HMDB01024 | 6.82_164.9577 m/z | 0.000 | 19.00 | Up |
Leucine/Isoleucine | L; Iso-L | HMDB00687; HMDB00172 | 6.55_168.0429 m/z | 0.003 | 7.84 | Up |
L-Cystine | Cystine | HMDB00192 | 4.81_221.0093 m/z | 0.008 | 2.67 | Up |
Serine t-RNA ligase | SARS | SYSC_HUMAN | XP_005610429.1 | 0.007 | 2.17 | Up |
Tyrosine t-RNA ligase | YARS | SYYC_HUMAN | XP_014592779.1 | 0.015 | 2.06 | Up |
Asparaginyl t-RNA ligase | NARS | SYNC_HUMAN | XP_001488269.1 | 0.016 | 3.19 | Up |
Threonine t-RNA ligase | TARS | SYTC_HUMAN | XP_001498225.2;XP_001491149.3 | 0.005 | 2.11 | Up |
Methionine t-RNA ligase | MARS | SYMC_HUMAN | XP_001488941.1;XP_005611399.1 | 0.039 | 2.12 | Up |
Alanine t-RNA ligase | AARS | SYAC_HUMAN | XP_001501062.3 | 0.013 | 34.61 | Down |
6 Purin & Pyrimidin Metabolism (proteins n = 8; metabolites n = 3) | ||||||
Ribose-phosphate pyrophosphokinase | PRPS1 | PRPS1_HUMAN | XP_001491425.1;XP_001489096.2;XP_001496502.1 | 0.011 | 2.09 | Up |
Phosphoribosylformylglycinamidine synthase | PFAS | PUR4_HUMAN | XP_001918417.1 | 0.006 | 14.09 | Up |
Bifunctional purine biosynthesis protein | PURH | PUR_9_HUMAN | XP_005610644.2 | 0.007 | 2.01 | Up |
Inosine-5′-monophosphate dehydrogenase 2 | IMDH2 | IMDH2_HUMAN | XP_001494600.4;XP_005600741.2 | 0.004 | 3.17 | Up |
Guanine Monophosphate Synthase | GMPS | GUAA_HUMAN | XP_014587031.1 | 0.003 | 2.23 | Up |
DNA-directed RNA polymerases I, II, and III subunit RPABC1 | POLR2 | RPAB1_HUMAN | XP_001496313.1;XP_014596768.1 | 0.026 | 3.93 | Up |
Bis(5′-adenosyl)-triphosphatase | ENPP4 | ENPP4_HUMAN | XP_001502639.1 | 0.005 | 5.49 | Down |
Hypoxanthine | HypoX | HMDB00157 | 4.75_172.9976 m/z | 0.014 | 2.62 | Up |
Guanosine | Guano | HMDB00133 | 4.63_318.0790 m/z | 0.033 | 4.29 | Up |
Deoxycytidine monophosphate | dCMP | HMDB01202 | 6.89_343.9941 m/z | 0.025 | 2.25 | Up |
Uridine 5′-monophosphate synthase | UMPS | UMPS_HUMAN | XP_001500089.4 | 0.009 | 3.17 | Up |
7 Steroid Metabolism (proteins n = 2; metabolites n = 2) | ||||||
Diphosphomevalonate decarboxylase | MVD | MVD1_HUMAN | XP_001488083.1;XP_014593934.1 | 0.007 | 6.21 | Up |
Growth Regulation by Estrogen in Breast Cancer Gene 1 | GREB | GREB1_HUMAN | XP_014586792.1 | 0.002 | 4.26 | Up |
Geranyl Pyrophosphate | Geranyl-PP | HMDB01285 | 4.89_314.0589n | 0.002 | 3.04 | Down |
Estrone Sulfate | Estrone-S | HMDB01425 | 6.98_385.0719 m/z | < 0.001 | 2.94 | Down |
8 Extracellular Matrix/Proteoglycans (proteins n = 11; metabolites n = 1) | ||||||
Vitronectin | VN | VTNC_HUMAN | XP_001504173.3 | 0.001 | 19.83 | Down |
Fibronectin | FN | FINC_HUMAN | XP_001489154.4 | < 0.001 | 152.88 | Down |
Inter-alpha-trypsin inhibitor heavy chain H1 | ITIH1 | ITIH1_HUMAN | XP_001492576.1;XP_014587106.1 | < 0.001 | 76.91 | Down |
Inter-alpha-trypsin inhibitor heavy chain H2 | ITIH2 | ITIH2_HUMAN | XP_001916967.1 | < 0.001 | 45.40 | Down |
Inter-alpha-trypsin inhibitor heavy chain H3 | ITIH3 | ITIH3_HUMAN | XP_014587105.1 | < 0.001 | 14.74 | Down |
Inter-alpha-trypsin inhibitor heavy chain H4 | ITIH4 | ITIH4_HUMAN | XP_005600608.1;XP_014587103.1 | 0.011 | 26.91 | Down |
Basement-membrane specific heparan sulfate proteoglycan core protein | HSPG2 | PGBM_HUMAN | XP_014592730.1 | 0.014 | 3.17 | Down |
Epidermal Growth Factor Receptor | EGFR | EGFR_HUMAN | XP_005609210.2 | 0.009 | 2.24 | Up |
Dystroglycan | DAG1 | DAG1_HUMAN | XP_001497663.1;XP_005600719.1;XP_005600720.1;XP_005600721.1 | 0.011 | 2.35 | Up |
Serine Protease HTRA1 | HTRA1 | HTRA1_HUMAN | XP_005602601.1 | 0.013 | 3.92 | Up |
Gap junction alpha 1 protein; Connexin-43 | GJA1 | CXA1_HUMAN | NP_001296155.1;XP_014584258.1;XP_014584259.1 | 0.008 | 2.69 | Down |
Chondroitin-4-sulphate | CHOND4 | HMDB00652 | 4.75_496.0430 m/z | 0.012 | 3.61 | Up |
9 Complement Cascade (proteins n = 14) | ||||||
Plasma protease C1 inhibitor | IC1 | IC1_HUMAN; SERPING1 | XP_001498388.1 | < 0.001 | 56.92 | Down |
Complement 4 (A/B) | C4 | CO4B_HUMAN | XP_001492943.1 | 0.007 | 7.78 | Down |
C4b-binding protein alpha chain | C4BP | C4BPA_HUMAN | XP_014594908.1 | 0.001 | 48.62 | Down |
C4b-binding protein alpha chain | C4BP | C4BPA_HUMAN | XP_001492582.2;XP_005609671.1;XP_005609672.1;XP_005609676.1;XP_005609677.1;XP_005609678.1;XP_014594955.1;XP_014594956.1;XP_014594957.1;XP_014594958.1 | < 0.001 | 73.54 | Down |
C3 = Complement C3 | C3 | CO3_HUMAN | XP_014596564.1 | 0.005 | 9274.92 | Down |
C3 = Complement C3 | C3 | CO3_HUMAN | XP_001915589.1 | 0.001 | 748.41 | Down |
Complement C5 | C5 | CO5_HUMAN | XP_014591698.1;zz|FGCZCont0049_P01031|CO5_HUMAN | 0.044 | 5.66 | Down |
Complement C7 | C7 | CO7_HUMAN | XP_005604353.1 | 0.004 | 33.92 | Down |
Complement factor I | CFI | CFAI_HUMAN | XP_014593434.1;XP_014593435.1;XP_014593436.1 | < 0.001 | 16.51 | Down |
Complement factor B | CFB | CFAB_HUMAN | XP_001492602.1 | 0.008 | 33.85 | Down |
Complement factor H X1 | CFH | CFAH_HUMAN | XP_001491754.3 | 0.019 | 70.12 | Down |
Complement factor H X5 | CFH | CFAH_HUMAN | XP_005608148.2 | 0.002 | 12.74 | Down |
Clusterin | CLUS | CLUS_HUMAN | NP_001075413.1 | 0.049 | 3.44 | Down |
Vitronectin | VN | VTNC_HUMAN | XP_001504173.3 | 0.001 | 19.83 | Down |
10 Coagulation Cascade (proteins n = 17) | ||||||
Fibrinogen alpha chain | FGA | FIBA_HUMAN | XP_005607860.1 | 0.001 | 43.25 | Down |
Fibrinogen beta chain | FGB | FIBB_HUMAN | XP_003364583.1 | < 0.001 | 55.46 | Down |
Fibrinogen gamma chain | FGG | FIBG_HUMAN | XP_001914833.2 | < 0.001 | 36.00 | Down |
Kininogen-1 | KNG | KNG1_HUMAN | XP_001499389.1;XP_005601930.1 | 0.008 | 14.66 | Down |
Prothrombin | F2 | THRB_HUMAN | XP_001490892.3 | 0.001 | 6.66 | Down |
Heparin Cofactor 2 | HEP2 | HEP2_HUMAN; SERPIND1 | XP_003365492.1 | 0.003 | 46.20 | Down |
Plasma serine protease inhibitor | IPSP | IPSP_HUMAN; SERPINA5 | XP_001496026.2 | 0.031 | 44.21 | Down |
Antithrombin 3 | ANT3 | ANT3_HUMAN; SERPINC1 | XP_014594947.1;zz|FGCZCont0237_P01008|ANT3_HUMAN | 0.001 | 8.46 | Down |
Plasma protease C1 inhibitor | IC1 | IC1_HUMAN; SERPING1 | XP_001498388.1 | <0.001 | 55.27 | Down |
Alpha-2-antiplasmin | A2AP | A2AP_HUMAN; SERPINF2 | XP_001504386.3;XP_005597710.1 | 0.005 | 10.84 | Down |
Alpha-2-macroglobulin | A2M | A2MG_HUMAN | XP_014596179.1 | 0.015 | 49.65 | Down |
Alpha-2-macroglobulin | A2M | A2MG_HUMAN | XP_014596181.1;XP_014596182.1 | 0.014 | 40.92 | Down |
Alpha-2-macroglobulin | A2M | A2MG_HUMAN | XP_001499173.2 | 0.000 | 15.00 | Down |
Plasminogen | PLG | PLMN_HUMAN | XP_001500552.3 | 0.027 | 16.17 | Down |
Alpha-1-antiproteinase 2 precursor | A1AT | A1AT_HUMAN | NP_001108005.1 | 0.001 | 35.00 | Down |
Alpha-1-antiproteinase 2 precursor | A1AT | A1AT_HUMAN | XP_005605481.1 | 0.001 | 33.45 | Down |
Alpha-1-antiproteinase 2 precursor | A1AT | A1AT_HUMAN | XP_001495905.2 | 0.001 | 27.21 | Down |