Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey

Wang, Hao; Zhu, Xiaoqi; Shen, Junyan; Zhao, En-Feng; He, Dajun; Shen, Haitao; Liu, Hailiang; Zhou, Yongxin

doi:10.1186/s12864-019-6089-z

BMC Genomics

Table 3 Down-regulated proteins, identified in aged of human

From: Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey

Number	Accession	protein symbol	Description	gene symbol	Mean ± SD	E_Value
1	Q76FE5	H2B	Histone H2B	ABCF2	0.31 ± 0.1	6.00E-28
2	Q13201	MMRN1	Multimerin-1	MMRN1	0.77 ± 0.18	0
3	P08571	CD14	Monocyte differentiation antigen CD14	CD14	0.48 ± 0.04	0
4	P13796	PLSL	Plastin-2	HEL-S-37	0.19 ± 0.08	0
5	P05556	ITB1	Integrin beta-1	ITGB1	0.42 ± 0.03	0
6	P02776	PLF4	Platelet factor 4	PF4	0.48 ± 0.17	2.00E-40
7	Q6Q788	APOA5	Apolipoprotein A-V	APOA5	0.75 ± 0.14	0
8	Q96PD5	PGRP2	N-acetylmuramoyl-L-alanine amidase	PGLYRP2	0.46 ± 0.14	0
9	P08697	A2AP	Alpha-2-antiplasmin	SERPINF2	0.51 ± 0.13	0
10	Q9UK55	ZPI	Protein Z-dependent protease inhibitor	SERPINA10	0.38 ± 0.1	0
11	P19823	ITIH2	Inter-alpha-trypsin inhibitor heavy chain H2	ITIH2	0.65 ± 0.08	0
12	P02760\|	AMBP	Protein AMBP	AMBP	0.38 ± 0.09	0
13	Q96KK5	H2A1H	Histone H2A type 1-H	HIST1H2AG	0.49 ± 0.07	2.00E-54
14	P04275	VWF	von Willebrand factor	VWF	0.48 ± 0.08	0
15	P12111	CO6A3	Collagen alpha-3(VI) chain	COL6A3	0.43 ± 0.09	0
16	Q9UGM5	FETUB	Fetuin-B	FETUB	0.24 ± 0.04	0
17	P15169	CBPN	Carboxypeptidase N catalytic chain	CPN1	0.71 ± 0.12	0
18	P22792	CPN2	Carboxypeptidase N subunit 2	CPN2	0.7 ± 0.2	0
19	Q5XIF6	TBA4A	Tubulin alpha-4A chain	TUBA4A	0.83 ± 0.18	0
20	P29622	KAIN	Kallistatin	SERPINA4	0.2 ± 0.07	0
21	P05452	TETN	Tetranectin	CLEC3B	0.43 ± 0.02	4.00E-116
22	P35858	ALS	Insulin-like growth factor-binding protein complex acid labile subunit	IGFALS	0.58 ± 0.14	0
23	P04196	HRG	Histidine-rich glycoprotein	HRG	1.76 ± 0.63	0
24	Q13790	APOF	Apolipoprotein F	APOF	1.40 ± 0.43	0
25	P55058	PLTP	Phospholipid transfer protein	PLTP	1.39 ± 0.11	0
26	P04070	PROC	Vitamin K-dependent protein C	LOC	1.87 ± 0.64	2.00E-35
27	P01764	HV303	Ig heavy chain V-III region VH26	IGHV3–49	1.32 ± 0.24	5.00E-42
28	O95445	APOM	Apolipoprotein M	APOM	1.40 ± 0.25	2.00E-110
29	P06702	S10A9	Protein S100-A9	S100	3.10 ± 1.59	6.00E-62
30	Q5R1X3	ACTB	Actin, cytoplasmic 1	LOC	2.23 ± 0.62	0
31	P05543	THBG	Thyroxine-binding globulin	SERPINA7	2.26 ± 0.56	0
32	P04278	SHBG	Sex hormone-binding globulin	SHBG	3.77 ± 0.14	4.00E-171
33	P10720	PF4V	Platelet factor 4 variant	PF4V1	1.35 ± 0.31	6.00E-33
34	P00748	FA12	Coagulation factor XII	F12	1.69 ± 0.70	0
35	P36955	PEDF	Pigment epithelium-derived factor	SERPINF1	1.45 ± 0.26	0
36	P19827	ITIH1	Inter-alpha-trypsin inhibitor heavy chain H1	ITIH1	2.16 ± 0.16	0

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