Fig. 4

a Whole genome tree of the 69 M. catarrhalis genomes used in ReVac. The four clades seen are labeled as, blue-indicating a sero-resistant clade, green-indicating a sero-sensitive clade, orange-indicating older isolates of M catarrhalis dating to 1932, and red-indicating misannotated M. canis genomes from NCBI. b Whole genome tree of 128 currently available M. catarrhalis genomes on NCBI, maintains the same topology as 4A. c A protein alignment tree of one of ReVac’s top candidates, which separates sero-sensitive and sero-resistant clades, but is absent in the other two clades (also present in the respective clades of (b)). d A protein alignment tree of the candidate iron transporter that replicates the whole genome tree topology