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Fig. 2 | BMC Genomics

Fig. 2

From: Analyses of inter-individual variations of sperm DNA methylation and their potential implications in cattle

Fig. 2

Characterization of sperm methylation haplotype blocks (MHBs) in cattle. a Length distribution of MHBs. b CG density (CG number per base pair) distribution of MHBs. c Co-localization of MHBs with known genomic elements. d Enrichment of MHBs in known genomic features. e Enrichment of MHBs in predicted chromatin core 15-states using chromHMM [25, 63]: 1 TssA: Active Tss; 2 TssAFlnk: Flanking active TSS; 3 TxFlnk: Transcrption at gene 5′ and 3′; 4 EnhA: Active enhancer; 5 EnhAATAC: Active enhancer & ATAC; 6 EnhWk: Weak active enhancer; 7 EnhPois: Poised enhancer; 8 EnhPoisATAC: Poised enhancer & ATAC; 9 EnhWkCTCFATAC: Weak enhancer & CTCF & ATAC; 10 ATAC: ATAC islands; 11 reprWkCTCF: Weak represeed CTCF; 12 BivFlnk: Flanking bivalent TSS/Enhancer; 13 ReprRC: Repressed Polycomb; 14 ReprPCWk: Weak repressed Polycomb; and 15 Quies: Quiescent/Low. f One example of MHB located in the exon 4 of predicted maternal imprinted gene GAREM1. Methylation levels of the MHB were low in sperm but high in oocyte

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BMC Genomics

ISSN: 1471-2164

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