Table 2 Spontaneous mutant mice with cleft lip

1

Clf2

cleft lip 2

[50]

7601909

Homozygous mutant mice show CL and CP at higher incidence.

CLP

2

Rpl38

ribosomal protein L38

[51, 52]

10889952; 21529712

Heterozygous mutant mice show CL and/or CP.

CLO, CLP, or CPO

3

Tbx10

T-box 10

[53, 54]

5297683; 15118109

Homozygous Tbx10^Tg/Tg (gain of function) mice show either unilateral or bilateral CL and CP.

CLP

4

Wnt9b (aka Clf1)

wingless-type MMTV integration site family, member 9B

[55]

16998816

Homozygous null mutant mice show either unilateral or bilateral CL with/without CP.

CLO or CLP

5

Zeb1

zinc finger E-box binding homeobox 1

[56, 57]

13539273; 10669096

Homozygous mutant mice show either unilateral or bilateral and either complete or incomplete CL and CP. Twirler is mouse line name.

CLP

6

A/HeJ

Not gene

[58]

7202260

10% mice show CL/P.

CLO or CLP

7

A/J

Not gene

[58, 59]

7202260; 7394720

10% mice show CL/P.

CLO or CLP

8

A/Wysn

Not gene

[58]

7202260

20–30% mice show CL/P.

CLO or CLP

9

CL/Fr

Not gene

[59,60,61]

5538410; 7102571; 7394720

20–40% mice show CL/P. The cleft frequency depends on the colony.

CLO or CLP