Table 3 Previously reported role of the candidate genes located in the genomic regions associated with RFI in Angus

BTA20

3.88–5.88

DUSP1-Dual Specificity Phosphatase 1

Up-regulated gene in muscle from efficient broilers [15] and adipose tissue from obese humans [16]

ERGIC1 - Endoplasmic Reticulum-Golgi Intermediate Compartment 1

Associated with MMWT in cattle [10]

RPL26L1-Ribosomal Protein L26 Like 1

Gene associated with MMWT in cattle [10] and up regulate in breast carcinoma [17]

STK10-Serine threonine kinase 10

Significantly associated with slaughter weight in beef cattle [18]

ATP6V0E1- ATPase H+ Transporting V0 Subunit E1

Involved in oxidative phosphorylation with up-regulation in rumen epithelium of low RFI cattle [19]

STC2-Stanniocalcin 2

Associated with RFI and MBW in cattle [20]; possible modulator of carcass and meat quality traits in beef cattle [21]. Overexpression resulted in postnatal growth restriction in mice [22]

CPEB4- Cytoplasmic Polyadenylation Element Binding Protein 4

Gene associated with rib eye area in Nelore [23]. Nearby a suggestive SNP (p-value 1.38e^− 05) for average daily gain in pig [24]

NEURL1B- Neuralized E3 Ubiquitin Protein Ligase 1B

Associated with day 2 of preadipocyte differentiation in chicken [25], nearby gene to the single nucleotide variants associated with body mass index in adult humans [26], nearby gene to significant SNP for longissimus dorsi muscle area in Hanwoo cattle [27]

BOD1- Biorientation Of Chromosomes in Cell Division 1

Inhibits PP2A-B56 regulating the function of Plk1 in mitotic cells at spindle poles and kinetochores [28]

BTA17

6.26–6.46

SDS- Serine Dehydratase, SDSL- Serine Dehydratase Like

Low expression in bovine jejunal epithelium tissue due to restricted dietary [29]

DTX1- Deltex E3 Ubiquitin Ligase 1

Regulates transcription in the nucleus downstream the Notch receptor [30]

SLC8B1- Solute Carrier Family 8 Member B1

Up-regulation in high-efficient broiler chickens [31]

OAS2–2′-5′-Oligoadenylate Synthetase 2

Up-regulated in Blonde d’Aquitaine during embryonic muscle developmental when contrasting with Charolais [32]

PTPN11- Protein Tyrosine Phosphatase, Non-Receptor Type 11

Down regulated gene in high-RFI Holstein [33], and control cell proliferation in postnatal mice [34]

RPL6- Ribosomal Protein L6

Differentially expressed gene in divergent RFI lines of pigs [35]

LHX5- LIM Homeobox 5

Regulates the development and distribution of Cajal-Retzius cells in the developing forebrain [36]

TPCN1- Two Pore Segment Channel 1

Mice with knock down of the Tpcn1/2 had increase body mass due to faster increase in fat mass compare with the wile mice [37]

BTA14

2.31–2.51

XKR4- XK Related 4

SNP associated with ADFI and ADG in cattle [38], and backfat thickness in Nelore [39]

SOX17- SRY-Box 17

Transcriptional regulator of differentiation in embryonic stem cells in mouse [40]. Significant SNP associated with EBV for paternal calving ease in cattle [41]

BTA1

1.10–1.11

VEPH1- Ventricular Zone Expressed PH Domain Containing 1

Candidate gene for rump fat thickness in Nellore [9]

PTX3- Pentraxin 3

Up-regulated in breast muscle of high-feed efficient broilers [42]

MFSD1-Major facilitator superfamily domain containing 1

Down-regulated gene in brainstem and hypothalamus of mice raised on high-fat diet [43]

BTA6

5.41–5.61

LOC104968862

LOC104968863

-un characterize proteins

Located in the region of SNPs for rump fat thickness [39]

BTA26

7.90–9.90

MINPP1- Multiple Inositol-Polyphosphate Phosphatase 1

Maintains the levels of InsP5 and InsP6 which are essential to normal cell growth [44]

A1CF- APOBEC1 Complementation Factor

Splicing regulator and the A1CF loss of function elevated triglycerides levels in mice [45]

PAPSS2–3′-Phosphoadenosine 5′-Phosphosulfate Synthase 2

Gene located nearby a SNP associated with DMI in feedlot steers [46]; After treating cartilage from bovine with TGF-β, the expression of gene PAPSS2 was up-regulated in articular chondrocytes, while the expression was down-regulated in cartilage from mice with negative mutation of the TGF-β receptor [47]

SGMS1- Sphingomyelin Synthase 1

Gene nearby a significant SNP associated with RFI in pigs [48] and average daily feed intake [49]

ASAH2- N-Acylsphingosine Amidohydrolase 2

Up-regulated in pigs with low feed conversion ratio [50]