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Table 4 Most significant gene expression associated with RFI and their related metabolic pathway

From: Combining information from genome-wide association and multi-tissue gene expression studies to elucidate factors underlying genetic variation for residual feed intake in Australian Angus cattle

Symbol

Effect

p-value

Dataseta

Pathway

NREP-Neuronal Regeneration Related Protein

−0.21

4.66E-06

BM

MECP2 and Associated Rett Syndrome

NAALADL1- N-Acetylated Alpha-Linked Acidic Dipeptidase Like 1

0.33

1.33E-05

HB

–

NCOA4- Nuclear Receptor Coactivator 4

0.18

1.49E-05

SL

Pathways in cancer, Thyroid cancer

CD8B- CD8b Molecule

0.34

1.97E-05

HB

T-Cell Receptor and Co-stimulatory Signaling, Innate Immune System

DHCR7–7-Dehydrocholesterol Reductase

−0.29

2.32E-05

BM

Regulation of cholesterol biosynthesis by SREBP (SREBF), cholesterol biosynthesis I

ENSBTAG00000039588

0.39

3.81E-05

HB

–

SYNE2- Spectrin Repeat Containing Nuclear Envelope Protein 2

0.11

4.01E-05

BM

Meiosis, Ovarian Infertility Genes

OLFML1- Olfactomedin Like 1

−0.51

4.56E-05

BM

–

ANGPTL2- Angiopoietin Like 2

−0.27

5.93E-05

BM

Common Cytokine Receptor Gamma-Chain Family Signaling Pathways

ACADSB- Acyl-CoA Dehydrogenase Short/Branched Chain

−0.29

6.29E-05

BL

Fatty acid degradation, Valine, leucine and isoleucine degradation, Metabolic pathways, Fatty acid metabolism

DDIT3- DNA Damage Inducible Transcript 3

−0.22

7.26E-05

BM

MAPK signaling pathway, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD), Transcriptional misregulation in cancer

TDRP- Testis Development Related Protein

−0.45

1.21E-04

HL

–

CCDC38- Coiled-Coil Domain Containing 38

0.68

1.67E-04

BL

–

AIM1- Absent in melanoma 1

0.15

1.91E-04

BL

Fatty acid degradation, alpha-Linolenic acid metabolism, Metabolic pathways, Biosynthesis of secondary metabolites, Fatty acid metabolism

PLA2G16- Phospholipase A2 Group XVI

0.18

2.32E-04

HL

Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, Metabolic pathways, Ras signaling pathway, Regulation of lipolysis in adipocytes

TMEM135- Transmembrane Protein 135

−0.21

2.50E-04

BM

–

CENPM- Centromere Protein M

0.45

2.82E-04

SL

Chromosome Maintenance, Signaling by Rho GTPases

EIF2A- Eukaryotic Translation Initiation Factor 2A

0.16

2.83E-04

BL

RNA transport, Protein processing in endoplasmic reticulum

SQLE- Squalene Epoxidas

−0.45

2.84E-04

BM

Steroid biosynthesis, Metabolic pathways, Biosynthesis of antibiotics

GSTT3- Glutathione S-Transferase Theta 3

0.27

2.91E-04

BL

Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Chemical carcinogenesis

HMGCS1–3-Hydroxy-3-Methylglutaryl-CoA Synthase 1

−0.24

2.94E-04

BM

Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism, Terpenoid backbone biosynthesis, Metabolic pathways, Biosynthesis of antibiotics

GHDC- GH3 Domain Containing

0.17

3.59E-04

HL

Innate Immune System

EIF3H- Eukaryotic Translation Initiation Factor 3 Subunit H

0.10

3.62E-04

BL

RNA transport, Measles

GPATCH11- G-Patch Domain Containing 11

0.33

4.14E-04

SL

–

NET1- Neuroepithelial Cell Transforming 1

−0.14

4.19E-04

HL

p75 NTR receptor-mediated signaling, fMLP Pathway

BCKDHB- Branched Chain Keto Acid Dehydrogenase E1 Subunit Beta

0.10

4.32E-04

SL

Valine, leucine and isoleucine degradation, Metabolic pathways, Biosynthesis of antibiotics

DNER- Delta/Notch Like EGF Repeat Containing

−1.13

4.33E-04

BM

Signaling by NOTCH1 and NOTCH2 Activation, Transmission of Signal to the Nucleus

ALDH5A1- Aldehyde Dehydrogenase 5 Family Member A1

0.14

4.81E-04

BL

Alanine, aspartate and glutamate metabolism, Butanoate metabolism, Metabolic pathways

ROBO2- Roundabout Guidance Receptor 2

0.49

5.03E-04

BL

Axon guidance

GSTM2- Glutathione S-Transferase Mu 2

0.61

5.51E-04

BL

Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Chemical carcinogenesis

PRICKLE1-Prickle Planar Cell Polarity Protein 1

−0.31

5.62E-04

BL

Wnt signaling pathway

ENSBTAG00000040281

0.59

6.02E-04

HB

–

IFI47- Interferon Gamma Inducible Protein 4

0.88

6.02E-04

SL

TNF signaling pathway

ENSBTAG00000002786

−1.10

6.42E-04

SL

–

RBP1- Retinol Binding Protein 1

0.55

7.01E-04

HB

Nicotinate and nicotinamide metabolism, Metabolic pathways

UBE2D2- Ubiquitin Conjugating Enzyme E2 D2

0.10

7.21E-04

SL

Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

ENSBTAG00000001489

−0.18

7.24E-04

SB

Phagosome, Gap junction

GDPGP1- GDP-D-Glucose Phosphorylase 1

0.32

7.40E-04

HB

–

ITGB4- Integrin Subunit Beta 4

0.34

8.59E-04

HL

PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Regulation of actin cytoskeleton, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy

URI1- URI1, Prefoldin Like Chaperone

0.19

9.32E-04

SL

Translational Control, Apoptosis and Autophagy

  1. aBM: bulls_muscle, HB: H-heifers_blood, SL: H-steers_blood, BL: A-bulls_liver, HL: H-heifers_liver
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BMC Genomics

ISSN: 1471-2164

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