Skip to main content

Table 2 Functional enrichment of non-redundant differentially expressed genes presenting higher variation in the skin of tick-resistant Braford cattle after tick infestation

From: Network analysis uncovers putative genes affecting resistance to tick infestation in Braford cattle skin

Category

Function Annotation

p-value

z-scorea

Genesb

Behavior

behavior

3.43E-04

−2.24

CRHR2, CSF2, DDO, DMRTA1, DRD3, GAD2, GAL, GRIA2, GRIK2, GRP, HBA1/HBA2, IL6, MAP6, NPTX2, SLC26A4, SYN1

Cardiovascular System Development and Function

development of cardiovascular system

4.14E-04

2.19

C6, CCR3, CRHR2, CSF2, FOSL1, HBA1/HBA2, HP, IL13RA2, IL20, IL24, IL6, MMP13, OLR1, OPTC, RETN, TNNT2, WNT7A

Cardiovascular System Development and Function, Organismal Development

angiogenesis

3.14E-04

2.19

C6, CCR3, CRHR2, CSF2, FOSL1, HP, IL13RA2, IL20, IL24, IL6, MMP13, OLR1, OPTC, RETN, WNT7A

vasculogenesis

1.37E-03

2.18

C6, CCR3, CRHR2, CSF2, IL13RA2, IL20, IL24, IL6, MMP13, OLR1, OPTC, RETN

Cell-To-Cell Signaling and Interaction

activation of cells

2.53E-04

3.38

C6, CD79B, CSF2, DRD3, F2RL3, GAD2, GRIK2, IL22, IL24, IL37, IL6, LBP, MMP13, RETN, SOST, TREML2

Cell-To-Cell Signaling and Interaction, Cellular Growth and Proliferation

stimulation of cells

1.34E-03

2.04

CCL20, CSF2, GAL, GRP, IL22, IL24, IL6

Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking

recruitment of granulocytes

1.55E-07

2.13

CCL20, CCR3, COCH, CSF2, GRP, IL22, IL37, IL6, OLR1, TREML2

Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response

recruitment of neutrophils

3.89E-07

2.21

CCL20, COCH, CSF2, GRP, IL22, IL37, IL6, OLR1, TREML2

Cell-To-Cell Signaling and Interaction, Hematological System Development and Function

activation of blood cells

1.39E-04

2.95

C6, CD79B, CSF2, DRD3, F2RL3, GAD2, GRIK2, IL22, IL24, IL37, IL6, LBP, RETN, TREML2

Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response

activation of leukocytes

2.93E-03

3.09

C6, CD79B, CSF2, DRD3, GAD2, IL22, IL24, IL37, IL6, LBP, TREML2

activation of phagocytes

2.26E-04

2.92

C6, CSF2, DRD3, IL22, IL24, IL37, IL6, LBP, TREML2

activation of myeloid cells

1.20E-04

2.90

C6, CSF2, DRD3, IL22, IL24, IL37, IL6, LBP, TREML2

activation of mononuclear leukocytes

1.92E-03

2.55

CD79B, CSF2, DRD3, GAD2, IL22, IL24, IL6, LBP, TREML2

activation of macrophages

1.61E-03

2.39

C6, CSF2, DRD3, IL37, IL6, LBP

Cellular Movement

migration of cells

7.32E-06

2.74

C6, CCL20, CCR3, COCH, CSF2, DRD3, F2RL3, FAT3, FGFR4, FOSL1, GRIA2, GRP, HP, IGFBP1, IL20, IL22, IL24, IL37, IL6, LBP, MGAT3, MMP13, NPTX2, OLR1, RETN, TREML2, VIL1, WNT7A

cell movement

8.23E-06

2.51

C6, CCL20, CCR3, COCH, CSF2, DRD3, F2RL3, FAT3, FGFR4, FOSL1, GRIA2, GRP, HP, IGFBP1, IL13RA2, IL20, IL22, IL24, IL37, IL6, LBP, LRRC6, MGAT3, MMP13, NPTX2, OLR1, RETN, TREML2, VIL1, WNT7A

chemotaxis of cells

2.32E-04

2.17

CCL20, CCR3, CSF2, DRD3, GRP, HP, IL20, IL22, IL6, LBP, TREML2

chemotaxis

7.34E-05

2.17

CCL20, CCR3, CSF2, DRD3, FOSL1, GRP, HP, IL20, IL22, IL6, LBP, TREML2

Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking

cell movement of leukocytes

1.82E-04

2.64

C6, CCL20, CCR3, CSF2, DRD3, GRP, HP, IL20, IL22, IL37, IL6, LBP, RETN, TREML2

cell movement of myeloid cells

6.05E-05

2.37

C6, CCL20, CCR3, CSF2, GRP, HP, IL20, IL22, IL6, LBP, RETN, TREML2

cell movement of granulocytes

1.04E-03

2.28

CCR3, CSF2, GRP, IL20, IL22, IL6, LBP, TREML2

Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response

cell movement of phagocytes

3.28E-04

2.42

C6, CCL20, CCR3, CSF2, GRP, HP, IL20, IL6, LBP, RETN, TREML2

cell movement of neutrophils

5.41E-03

2.41

CSF2, GRP, IL20, IL6, LBP, TREML2

chemotaxis of granulocytes

5.23E-04

2.35

CCR3, CSF2, GRP, IL20, LBP, TREML2

chemotaxis of myeloid cells

1.88E-04

2.15

CCL20, CCR3, CSF2, GRP, HP, IL20, LBP, TREML2

chemotaxis of neutrophils

1.62E-03

2.15

CSF2, GRP, IL20, LBP, TREML2

chemotaxis of leukocytes

2.79E-05

2.14

CCL20, CCR3, CSF2, GRP, HP, IL20, IL22, IL6, LBP, TREML2

Cellular Movement, Immune Cell Trafficking

leukocyte migration

6.68E-05

2.55

C6, CCL20, CCR3, COCH, CSF2, DRD3, GRP, HP, IL20, IL22, IL37, IL6, LBP, OLR1, RETN, TREML2

Developmental Disorder

Hypertrophy

5.84E-03

2.35

CSF2, GAL, GRP, IL6, RRAD, SOST, TNNT2, WNT7A

Free Radical Scavenging

synthesis of reactive oxygen species

4.37E-04

2.19

CCR3, CSF2, HBA1/HBA2, HP, IL24, IL6, OLR1, PEBP4, RETN, TREML2

Hematological System Development and Function, Tissue Morphology

quantity of blood cells

3.84E-03

2.31

C6, CCL20, CCR3, CD79B, CSF2, GAD2, HBA1/HBA2, IGFBP1, IL13RA2, IL22, IL6, IL9R, MMP13, SPTA1

Inflammatory Response

inflammatory response

1.38E-05

2.59

C6, CCL20, CCR3, CSF2, DRD3, GAL, GRP, HP, IL20, IL22, IL24, IL37, IL6, LBP, OLR1, TREML2

Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry

concentration of lipid

3.37E-04

2.02

CRHR2, CSF2, FGFR4, GAD2, GAL, GRP, HP, IL6, LBP, MGAT3, OLR1, RETN, RRAD, SOST

secretion of lipid

3.43E-04

2.00

CSF2, DRD3, GAL, GRP, IL6, RETN

Lipid Metabolism, Small Molecule Biochemistry

synthesis of lipid

3.48E-03

2.40

CCR3, CRHR2, CSF2, FGFR4, FOSL1, GAD2, GRP, IL24, IL6, OLR1, RETN

Molecular Transport

secretion of molecule

7.96E-05

2.32

ATP4B, CRHR2, CSF2, DRD3, GAL, GRP, IL6, OLR1, RETN, SLC26A4, SYN1, WNT7A

transport of molecule

1.18E-03

2.21

ACTN2, ATP4B, ATP6V1G2, CRHR2, CSF2, DRD3, GAL, GRIA2, GRIK2, GRP, HBA1/HBA2, IL6, KCNH4, LBP, OLR1, RETN, SLC26A1, SLC26A4, SYN1, WNT7A

Organismal Development

formation of vessel

4.01E-04

2.00

CRHR2, CSF2, IL6, OLR1, OPTC

  1. aactivation z-score (|z-score| > 2)
  2. bnon-redundant TopDEGs (|log2| FC > 1)
Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us