Fig. 1

Age-dependent changes of macromolecules. a Median human protein turnover for taxonomic groups. Number of proteins: u org = 904, u euk = 1745, OBD = 749, chor = 378, mamm = 77. b Variance of median protein turnover for taxonomic groups in (a). c Median human protein aggregation propensity for taxonomic groups. Number of proteins: u org = 1842, u euk = 4005, OBD = 3745, chor = 4191, mamm = 2127. d Median level of protein disorder for taxonomic groups. Number of proteins: u org = 1943, u euk = 4377, OBD = 4129, chor = 4680, mamm = 2787. e Median protein abundance for taxonomic groups. Number of proteins: u org = 904, u euk = 1745, OBD = 749, chor = 378, mamm = 61. f Median mRNA half-lives for taxonomic groups. Number of mRNA species: u org = 903, u euk = 2055, OBD = 1117, chor = 538, mamm = 63 (g) Median human translation efficiency. Number of proteins: u org = 1219, u euk = 2948, OBD = 2039, chor = 1428, mamm = 21. h Median gene conservation score for taxonomic groups. Number of genes: u org = 1904, u euk = 4280, OBD = 3984, chor = 4539, mamm = 1768. (ANOVA, Bonferroni post-hoc analysis for all histograms except Fig. 1b)