Table 3 Number of differentially expressed gene (DEG) associated with immune-related KEGG pathways determined in both head kidney and liver for peptidoglycan (PGN) and poly I:C treated fish, assessed by comparison of against PBS-treated fish in each same group. Total number of DEGs of each genotype were different from the sum of values because some genes have multi-functional characteristics by KEGG pathway analysis

Antigen processing and presentation

APP

2

2

2

2

1

3

Complement and coagulation cascades

CCC

1

1

1

2

1

1

Cytosolic DNA-sensing pathway

CDs

0

1

1

C-type lectin receptor signaling pathway

CLRs

1

1

2

1

1

1

Chemokine signaling pathway

Cs

2

1

2

3

1

1

4

Fc gamma R-mediated phagocytosis

FGRP

2

1

1

1

3

0

Intestinal immune network for IgA production

IINIP

0

1

1

IL-17 signaling pathway

ILs

1

2

1

1

2

1

1

2

Leukocyte trans-endothelial migration

LTM

2

1

1

3

1

3

0

NOD-like receptor signaling pathway

NRs

1

1

3

1

2

1

4

Platelet activation

PA

1

1

0

RIG-I-like receptor signaling pathway

RRs

0

2

1

3

3

Th17 cell differentiation

TCD

0

1

1

1

1

3

Toll and Imd signaling pathway

TIs

1

1

2

2

0

Toll-like receptor signaling pathway

TRs

2

2

2

2

1

2

Th1 and Th2 cell differentiation

TTCD

0

1

1

1

9

1

3

1

13

3

10

21

18

4

8

7

15

3.0

3.3

6.9

10.9

15.8

5.5

2.8

9.0

12.8

7.3

7.9

4.2

16.0