Fig. 2

Genomic distribution of differentially methylated regions (DMRs). a Distribution of significant DMRs on 30 chromosomes of Bos taurus. Horizontal axis displays the chromosome length; 1–14 legend insert indicates the DMR density within 1 Mbp window size. b Scatterplots showing correlation of DMRs with number of genes per chromosome (left) and size of chromosomes (right). The Pearson’s correlation coefficients are shown on each plot. c Scatterplot showing distribution of DMRs against all targeted CpG regions (100 bp) on each chromosome. Colour intensity shows CG dinucleotide occurrence (million as unit) in the chromosomes. d Pie chart shows percentages of DMRs location in CpG islands, shores and other genomic regions. e Bar plot and pie chart shows distribution of DMRs in genic and non-genic regions. Exons and introns have annotation precedence over promoter regions, which are downstream (2 kb) of transcription-start sites (TSSs). For promoters, only DMRs 2 kb upstream of TSSs are shown