Fig. 5

Overwiew on signaling pathways core genes in bee genomes. Shown are the core genes of the Hippo, Notch, TGF-β, Wnt, and insulin signaling pathways in the genome of F. varia compared to 13 other sequenced and annotated bee genomes. Hippo: d: dachs, ds: dachsous, dco: discs overgrown, ex: expanded, ft.: fat, hpo: hippo, kibra: Kibr, mats: mob as tumor suppressor, Mer: Merlin, sav: Salvador, sd: Scalloped, wts: Warts, yki: Yorkie.Notch: ADAM: ADAM 17-like protease, aph-1: anterior pharynx defective 1, CIR: corepressor interacting with RBPJ 1, CtBP: C-terminal binding protein, Dl: delta, dx: deltex, fng: fringe, PSE2: presenilin enhancer, HATs: histone acetyltransferase KAT2A, HDAC1: histone deacetylase 1, nct: nicastriin, N: notch, numb: numb, Psn: presenilin, gro: groucho, Ser: serrate, SKIP: puff-specific protein Bx42, Dvl: segment polarity protein dishevelled homolog DVL-3, Su(H): suppressor of hairless. TGF-β: babo: baboon, Dad: Daughters against dpp, dpp: decapentaplegic, gbb: glass bottom boat, Mad: Mothers against dpp, Med: Medea, put: punt, sax: saxophone, shn: schnurri, Smox: Smad on X, tkv: thickveins, wit: wishful thinking. WNT: Wnt1: wingless-type MMTV integration site family, member 1, Wnt10: Wnt oncogene analog 10, Wnt6: Wnt oncogene analog 6, Notum: Notum, Bambi: Bambi, Axn: Axin, nkd: naked cuticle, CycD: Cyclin D. Insulin: akt1: Akt1, chico: chico, foxo: forkhead box, sub-group O, Pdk1: Phosphoinositide-dependent kinase 1, Pi3K92E: Pi3K92E, Pten: Phosphatase and tensin homolog, Tor: Target of rapamycin, Ilp2: Insulin-like peptide 2, InR: Insulin-like receptor