Fig. 3
From: Quantitative characterization of tumor cell-free DNA shortening
Fragment size of cfDNA from regions with different chromatin accessibility. a Fragment length distribution in 4 lung or gastric cancer patients within the 2000 bp region centered around the TSSs of 3717 housekeeping genes and 325 unexpressed genes. b cfDNA size ratio of lung cancer patient P1 (SRX1921677) mapped to the 2000 bp region centered around the TSSs of genes with different expression levels according to A549 cell line. c cfDNA size ratios of lung cancer patients (SRX1921677 and SRX1921680), a gastric cancer patient (SRX1921678), and a healthy control (SRX1120814) in genomic regions with different DHS signals. DHS sites were grouped based on DHS signal quantiles as determined in lung adenocarcinoma cell line A549 and/or healthy lymphocyte cell line GM12878. d Fragment length distribution of cfDNA of lung cancer patient P1 (SRX1921677) from regions with histone mark H3K4me3 and H3K9me3 in A549 cell line