Fig. 3
From: SOX10-regulated promoter use defines isoform-specific gene expression in Schwann cells
Assessment of SOX10-associated transcription start sites in ΔSOX10 S16 cells. a Expression profiles of TSSs associated with SOX10-bound promoters in sciatic nerve, measured in ΔSOX10 S16 cells compared to unmodified S16s. Downregulated by loss of SOX10 (pink), upregulated by loss of SOX10 (purple), unchanged (blue), or not expressed in either condition (black). b In vivo expression levels of TSS classes (as in panel A). X-axis: log10 transformed average expression level (reads per million, RPM). Y-axis: the cumulative fraction of TSSs. Asterisk indicates p < 0.05. c Per-sample expression levels for TSSs associated with enriched gene ontology terms among TSSs that are downregulated upon loss of SOX10. Expression values are scaled per TSS (Z-score)