Fig. 1

Integrating binding and expression data to predict the combined function of two transcription factors. The binding peaks from ChIP experiments of two factors are used to find their shared binding sites in the regions of interest. The distances between the peaks and the regions are used to calculate peak scores. The sum of the scores of all peaks assigned to a region is its regulatory potential. The product of signed statistics from gene expression profiling of the factors perturbation is used to determine the magnitude and the direction of their regulatory interactions. The products of the ranks of the regulatory potential and the regulatory interactions are used to rank the regions of interest