Fig. 3From: Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infectionHeatmap of log2FC values with hierarchical clustering of genes based on V + F contrast uniquely differentially expressed genes (DEG) in the fetal placenta, thymus, or identified as DEG in both placenta and thymus. A) uniquely DEG genes in the placenta of V + F. B) DEG that were identified in both placenta and thymus of V + F. C) uniquely DEG in the thymus of V + F. The log2FC for each group was calculated in contrast to control (CTRL); 1. uninfected (UNINF), 2. placenta only with viable (PLCO-VIA), 3. PLCO with meconium staining (PLCO-MEC), 4. low viral load with VIA (LVL-VIA), 5. LVL-MEC, 6. high viral load VIA (HVL-VIA) and 7. HVL-MEC. 8. V + F calculated as (LVL-VIA, LVL-MEC, HVL-VIA, and HVL-MEC) contrasted to V - F (UNINF, PLCO-VIA, and PLCO-MEC). 9. MEC + F calculated as (PLCO-MEC, LVL-MEC, and HVL-MEC) contrasted to MEC - F (UNINF, PLCO-VIA, LVL-VIA, and HVL-VIA). The color corresponds to a gradient of the log2FC values ranging from downregulated in blue to upregulated in redBack to article page