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Table 1 Key expression differences in the central platelet signalling cascade

From: Comparison of the central human and mouse platelet signaling cascade by systems biological analysis

gene symbol/full name

cascade position*

experimental data

higher abundant in human

 TLN1 Talin 1

central, increased in human

[15, 18,19,20,21,22,23,24,25,26,27,28]

 CALM3 Calmodulin 3

2nd neighbour*, increased in human

[15, 18, 21,22,23, 26, 27]

 PRKCB Protkinase Ca

2nd neighbour, strong increase in human

[15, 18,19,20,21,22,23,24,25, 27]

 APP amyloid ßA4b

2nd neighbour, clearly increase in human

[15, 18,19,20,21,22,23,24,25]

 SOD2 SuperoxidDisc

2nd neighbour, clearly increase in human

[15, 18,19,20,21, 23,24,25, 27]

 TIMP1 Protease inhibd

2nd neighbour, clearly only human, T

[15, 18, 20,21,22, 24]

Only Human

 PLCB2 Phospholipase Ce

central, only human, good expressed)

[15, 18,19,20,21,22, 24]

 MMP9 Metalloproteasef

1st degree*, only human, low expressed

[15, 20]

 BDNF brain derived factorg

2nd degree*,

[15, 18, 20, 22]

 ITPR3 triphosphat receptorh

central, low expression

[15, 18]

 SLC25A6 Solute carrieri

3rd degree*, low expressed

[15, 18, 20,21,22,23,24]

higher abundant in mouse

 RASGRP2 Guanyl releasej

1st neighbour

[15, 18,19,20,21,22,23,24,25,26,27]

 ITGB2 Integrin Beta 2

1st neighbour, good difference,

[15, 20, 25,26,27]

 MYL9 myosin regulationk

2nd neighbour, high expression/ difference

[15, 18, 20,21,22,23,24,25,26,27]

 EIF4EBP1 initiation factorl

1st neighbour, very clear difference

[15, 20, 25, 26]

 ADAM17 metallopeptidasem

3rd neighbour, clear difference

[15, 18, 19, 25, 26]

 ARRB2 Arrestin ß2

1st neighbour, good difference

[15, 18, 20, 25, 26]

 CD9 Complementn

2nd neighbour, good marker, higher in mouse

[15, 18, 20,21,22,23,24,25, 27]

 SOD1 SuperoxidDisc

2nd neighbour, high abundant in both

[15, 18,19,20,21, 24,25,26,27]

 ZYX Zyxin protein

1st neighbour, high expression in both

[15, 18,19,20,21,22,23,24,25,26,27,28]

Only Mouse

 GNG12 Guanin bindingo

2nd degree, high expression, clear difference

[15, 25,26,27]

 PRKCE protein kinase Cε

2nd degree, high expression, clear difference

[15, 25, 26]

 ADCY9 Adenylate Cyclase 9

2nd degree, high expression, clear difference

[15, 25, 26]

Divergent expression levels comparing RNA versus protein

Glycoprotein VIb (only form present in platelets)

For GP6b (glycoprotein VIb (platelet) the mRNA level tends to be increased in mice, but the protein level shows clearly higher abundance in human (mouse higher in transcriptome whereas human higher in proteome)

SRC / Src protein kinase shows different mRNA and protein level regulation in man and mouse (human higher in transcriptome whereas mouse higher in proteome); the higher proteome expression has a clear effect on the switching behaviour of SRC as bistability switch (13)

  1. *Neighbor definition: see methods overview; 2nd degree = 2nd degree neighbor; 3rd degree = 3rd degree neighbor
  2. Abbreviations: aProtkinase C Protein kinase C, isoform B, bamyloid ßA4 amyloid beta A4 percursor protein, cSuperoxidDis superoxide dismutase, d Protease inhib TiM metallopeptidase inhibitor 1, ePhospholipase C Phospholipase C, isoform B2, fMetalloprotease Matrixmetalloprotease 9, gBDNF Brain derived neurotrophic factor, hITPR3 inositol 1,4,5 triphosphat receptor type 3, iSLC25A6 Solute carrier family 25 (mitochondrial) member 6, jRASGRP2 RAS-Guanyl releasing protein 2, kmyosin regulation myosin light polypeptide 9, lEIF4EBP1 eukaryotic translation initiation factor 4E binding protein1, mmetallopeptidase ADAM metallopeptidase domain 17, nCD9 antigen Complement defining protein 9, oGuanin binding Guanin nucleotide binding protein gamma 12
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BMC Genomics

ISSN: 1471-2164

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