Fig. 4

Transcriptional regulators as potential therapeutic targets in ischemic stroke treatment for female animals. a. Medium-confidence STRING network showing Rattus norvegicus protein-protein interactions of differentially expressed gene products annotated to the PANTHER protein class, gene-specific transcriptional regulator (108 annotated genes from the geneset), for the occluded middle cerebral artery experimental group. We identified 3 clusters formed by 16, 9 and 7 gene products. b. Five, 3 and 5 overrepresented GO biological process terms (cut-off: at least 5 annotated genes) were identified for cluster 1, 2 and 3 shown in a, respectively. The gene-specific transcriptional regulators were involved in biological processes such as neurogenesis, response to cytokine and regulation of cell differentiation