Fig. 6

Further analysis of the upregulated gene targets in the female rat middle cerebral arteries (MCAs). a. Heatmap and dendrograms illustrating hierarchical clustering of the expression of the gene targets for the experimental groups, occluded MCAs (R), non-occluded MCAs (L) and control MCAs (C), based on outcomes from the Affymetrix whole-transcriptome expression profiling (microarray analysis). The highest gene expression of ADAM metallopeptidase with thrombospondin type 1 motif 4 (Adamts4), C-C motif chemokine 2 (Ccl2), Fos-like antigen 1 (Fosl1), Jun B proto-oncogene (JunB), oxidized low density lipoprotein receptor 1 (Olr1), sphingosine-1-phosphate receptor 3 (S1pr3), serpin peptidase inhibitor, clade E member 1 (Serpine1) and suppressor of cytokine signaling 3 (Socs3) were observed for the occluded MCAs. b. Dot plot showing categorization of the gene targets, Adamts4, Ccl2, Fosl1, JunB, Olr1, S1pr3, Serpine1 and Socs3, into selected GO terms within the biological process domain. All gene targets were annotated to response to stress