Table 1 Gene enrichment analysis for the occluded middle cerebral arteries (MCAs) from female rats. Overview of the top 15 overrepresented gene ontology (GO) biological process terms with the highest fold enrichment and top 15 overrepresented GO biological process terms with lowest p-value identified for the differentially expressed genes in the occluded MCAs compared with control MCAs

Protein synthesis and modification

rRNA processing, GO:0006364

7.20E-09

3.25

58

216

Protein autophosphorylation, GO:0046777

1.23E-05

2.94

48

198

Positive regulation of transcription by RNA polymerase II, GO:0045944

1.21E-08

1.77

186

1270

Oxidative stress

Response to hydrogen peroxide, GO:0042542

4.19E-06

3.25

44

164

Cellular response to reactive oxygen species, GO:0034614

6.48E-04

2.88

39

164

Cellular response to hypoxia, GO:0071456

1.69E-03

2.86

37

157

Regulation of reactive oxygen species metabolic process, GO:2000377

2.54E-03

2.54

44

210

Inflammation

Cellular response to interleukin-1, GO:0071347

4.75E-04

3.22

34

128

Cellular response to tumor necrosis factor, GO:0071356

4.10E-04

2.73

44

195

Cellular response to lipopolysaccharide, GO:0071222

1.84E-05

2.72

53

236

Inflammatory response, GO:0006954

2.12E-05

2.22

78

425

Molecular “switches”

Stress-activated protein kinase signaling cascade, GO:0031098

2.61E-03

3.16

31

119

Response to cAMP, GO:0051591

1.68E-03

2.91

36

150

Positive regulation of GTPase activity, GO:0043547

1.84E-06

2.49

70

341

G protein-coupled receptor signaling pathway, GO:0007186

1.64E-21

0.32

55

2088

Tissue repair and recovery

Positive regulation of angiogenesis, GO:0045766

5.50E-04

2.81

42

181

Positive regulation of cell migration, GO:0030335

8.91E-11

2.38

111

565

Cellular response to growth factor stimulus, GO:0071363

7.66E-06

2.10

92

531

Epithelium development, GO:0060429

1.83E-05

1.72

150

1058

Cell death

Intrinsic apoptotic signaling pathway, GO:0097193

3.91E-02

2.63

33

152

Negative regulation of apoptotic process, GO:0043066

1.76E-05

1.78

137

934

Other

Cellular response to antibiotic, GO:0071236

1.04E-03

2.76

41

180

Regulation of cellular response to stress, GO:0080135

2.47E-08

2.10

119

688

Cellular response to organic cyclic compound, GO:0071407

1.21E-06

2.02

110

661

Negative regulation of multicellular organismal process, GO:0051241

5.19E-12

1.88

204

1312