Table 2 ROH island observed in < 3 populations and the associated genes and KEGG pathways

ROH ISLAND

CHR

BREEDS

GENES

KEGG PATHWAY

ROH2

1

BHP

ST3GAL3.

Metabolism (sphingolipid metabolism).

ROH199

18

BHP

BTBD1

Fanconi anaemia pathway

WHAMM

Tight junction

BLM

Fanconi anaemia pathway

FES

Biosynthesis of secondary metabolites

FANCI

Fanconi anaemia pathway

PLIN1

Regulation of lipolysis in adipocytes; Thermogenesis

PEX11A

Peroxisome

ANPEP

Renin-angiotensin system; Hematopoietic cell lineage; Metabolic pathways

HDDC3

Purine metabolism; Metabolic pathways

ROH100

6

BHP

ADRA2C

CGMP-PKG signalling pathway

GRK4

Chemokine signalling pathway; Endocytosis

SH3BP2

Natural killer cell mediated cytotoxicity

PIGG

Prodigiosin biosynthesis; Metabolic pathways

ROH101

6

NGU

ADRA2C

CGMP-PKG signalling pathway

GRK4

Chemokine signalling pathway; Endocytosis

SH3BP2

Natural killer cell mediated cytotoxicity

PIGG

Prodigios in biosynthesis; Metabolic Pathways

ROH108

7

SAM

DAAM1

Wnt signalling pathway

L3HYPDH

Arginine and proline metabolism

ROH149

12

MCM

IL10

Cytokine-cytokine interaction; Toxoplasmosis; Tuberculosis; Various diseases

ROH11

1

NGU & MCM

PRR4

Circadian rhythm – plant

S100A9

IL-17 signalling pathway

CRTC2

Glucagon signalling pathway, Insulin resistance

RAB13

Tight junction

TPM3

Cardiac muscle contraction

IL6R

Viral protein interaction with cytokine and cytokine receptor

ROH51

3

NQA & MCM

TPRN

Type I diabetes mellitus

VAV2

Rap1 signalling pathway

SARDH

Glycine, serine and threonine metabolism

ABO

Metabolic Pathways

ROH58

3

BHP & RDA

FSHR

Ovarian steroidogenesis

LHCGR

Prolactin signalling pathway

ROH75

4

BHP & MCM

VPS41

Salmonella infection; Autophagy - yeast

AMPH

Inflammatory mediator regulation of TRP channels; Biosynthesis of secondary metabolites; Metabolic Pathways; Fc gamma R-mediated phagocytosis

WNT16

Signalling pathways regulating pluripotency of stem cells; Melanogenesis

ROH125

9

BHP & SAM

AASS

Lysine degradation; Metabolic pathways Biosynthesis of secondary metabolites;

MSC

Sulfur metabolism; Degradation of aromatic compounds; Microbial metabolism in diverse environments; Metabolic pathways; Staphylococcus aureus infection

TRPA1

Inflammatory mediator regulation of TRP channels

RDH10

Retinol metabolism

UBE2W

Ubiquitin mediated proteolysis

LY96

NF-kappa B signalling pathway; Toll-like receptor signalling pathway; Salmonella infection; Pertussis; Toxoplasmosis

ROH200

18

BHP & SAMM

CTSH

Lysosome; Apoptosis

RASGRF1

Ras signalling pathway; MAPK signalling pathway; Focal adhesion

BCL2A1

NF-kappa B signalling pathway; Apoptosis

FAH

Microbial metabolism in diverse environments; Metabolic pathways; Nitrogen metabolism

IL16

Cytokine-cytokine receptor interaction

MCEE

Carbon metabolism; Metabolic pathways; Microbial metabolism in diverse environments; Valine, leucine and isoleucine degradation

FAN1

Fanconi anaemia pathway

ROH11

1

NGU & MCM

S100A9

IL-17 signalling pathway

S100A8

IL-17 signalling pathway

BGLAP

Parathyroid hormone synthesis, secretion and action

ARHGEF2

Pathogenic Escherichia coli infection; Tight junction; Bacterial invasion of epithelial cells; Salmonella infection

ASH1L

Metabolic pathways; Lysine degradation

FDPS

Biosynthesis of secondary metabolites; Metabolic pathways

ROH232

24

BVS; RDA; SAMM

STUB1

Protein processing in endoplasmic reticulum; Ubiquitin mediated proteolysis

SSTR5

Growth hormone synthesis, secretion and action; cAMP signalling pathway

UBE2I

Ubiquitin mediated proteolysis; RNA transport

GNPTG

Lysosome

ORAI2

Calcium signalling pathway

POR

RNA transport; ABC transporters; Protein digestion and absorption; Carbohydrate digestion and absorption; Glycolysis / Gluconeogenesis