Fig. 2

Proteomic analysis of C. albicans. a Volcano plot of differentially expressed proteins. The red points represented 548 proteins that were up-regulated in spaceflight group (adjusted P < 0.05; fold change ≥1.2). The blue points represented 332 proteins that were down-regulated in spaceflight group (adjusted P value < 0.05; fold change ≤0.83). b Hierarchical clustering of C. albicans proteomes. The heat map represented the Z scores of all proteins quantified in TMT technology. c PCA analysis of C. albicans proteomes. d Enriched KEGG pathways in up-regulated (red) and down-regulated (blue) proteins of spaceflight group. The x-axis shows the enrichment significance presented with –log10 (P value)