Table 1 The genes with high frequency in 13 “sKLD-signaling genes” groups in the critical stage (stage IIA) for LUSC
From: Identifying critical state of complex diseases by single-sample Kullback–Leibler divergence
Gene | Frequency | Location | Family* | Relation with cancer progression |
|---|---|---|---|---|
BIRC5 | 13 | Cytoplasm | other | The miR-195 axis regulates lung squamous cell carcinoma (LUSC) progression through BIRC [39]. |
CCNA2 | 13 | Nucleus | other | CCNA2 promotes invasion and migration of non-small cell lung cancer cells through integrin αvβ3 signaling pathway [40]. |
CDC6 | 13 | Nucleus | other | miR-26a/b inhibits directly migration, invasion, and proliferation of lung cancer cells by targeting CDC6 [41]. |
CKS1B | 13 | Other | kinase | CKS1B is a lung cancer-related gene, knockdown of which can result in a significant decrease in lung cancer cell proliferation, invasion and migration [42]. |
E2F8 | 13 | Nucleus | transcription regulator | Depletion of E2F8 inhibits cell proliferation and tumor growth in lung cancer, thus E2F8 can be considered as a novel therapeutic target for lung cancer [43]. |
FOXM1 | 13 | Nucleus | transcription regulator | Knockdown of FOXM1 inhibits the cell proliferation in LUSC [44]. |
ITPKA | 13 | Cytoplasm | kinase | ITPKA serves as an early diagnostic marker in lung cancer, whose overexpression promotes tumorigenesis [45]. |
MCM2 | 13 | Nucleus | enzyme | MCM2 regulates proliferation and cell cycle in lung squamous cell carcinoma, whose overexpressed protein is obviously associated with malign differentiated degree and lymph node metastasis [46]. |