Fig. 2

C > T polymorphism rate and methylation proportion around each type of CGIs. a Normalized incidence of C > T mutation according to the distance from the border of the CGIs. In the CGI shores, as the distance from the border of CGI becomes closer, the mutation rate of C > T is lower. Beyond 2 kb, the mutation rate of C:G > T:A plateaus. As a control, the normalized incidence of the C > T mutation at the non-CpG contexts is also depicted as grey dots. b The normalized incidence of the C > T mutation for each CGI type. In the CGI shores of the intragenic-coding CGIs, the incidence of C > T mutations is higher compared to the other CGIs. The normalized incidence of C > T mutations in the TSS-coding CGIs and TSS-noncoding CGIs tended to be lower than that of the non-TSS CGIs. c The pattern of the mean methylation percentage in each CGI type according to the distance from the border of CGIs. On the whole, the methylation percentage in the CGI shores is well correlated with the order of the normalized incidence of C > T mutations shown in (B). d Violin plots of the distribution of the mean methylation proportion according to each CGI type. The methylation pattern of the Intragenic-coding CGIs uniquely shows the bimodal distribution. e Intragenic coding CGIs with a mean methylation of > 67 and < 33% are classified as group A and B, respectively. Interestingly, the size of the CGIs in Group A is significantly shorter than that of the CGIs in Group B. f Mean mutation rate of the CGIs in Group A and B