Fig. 2

Genome-Wide Association (a) –log₁₀ P-values for each polymorphism (MAF ≥ 0.05, < 30% missing) in association with lifespan on H₂O₂ food, P-values above 0.01 not shown, the FDR of 0.2 level of significance is shown by a blue line. Inset shows a locus on chromosome 2 L that includes 6 resistance-associated SNPs in LD (r ≥ 0.5) and several candidate genes, including ush. Genes shown in blue were significant in gene-level analysis (FDR < 0.5). b A pairwise LD plot for all 14 resistance-associated SNPs (FDR < 0.2), groups of SNPs in LD are indicated with bars across the top, and a color scale for r is shown. c A Q-Q plot of –log₁₀ P-values for the variants tested in the GWAS showing little to no inflation after adjusting for population structure (Methods)