Table 6 The significant KEGG pathways with over- or under-expressed DEGs for three endometrial cell types (ST, GE and LE) were identified using DAVID database (adjusted p-value < 0.05)
cell type | under/over | KEGG Pathway Id | pathway name | genes |
|---|---|---|---|---|
Stromal cells | over-expressed | map 04020 | calcium signaling | P2RX3, ITPKA, ITPR2, CHRM3, ERBB3, CAMK2B, PLN, PLCB4, SLC25A4, HTR2A, MYLK, ADCY8, TACR1, PTGFR, PTGER3, RYR3, GRIN1 |
map 04530 | tight junction | OCLN, IGSF5, MYH14, CLDN23, PRKCZ, MYH11, CGN, TJP3, LLGL2, CLDN8, CLDN3 | ||
under-expressed | map 05162 map 05164 | measles and influenza A | JAK1, DDX58, ADAR, STAT1, IFIH1, EIF2AK2, IFNGR2, MX1, OAS1Z, OAS1Y, IRF7 | |
Glandular cells | over-expressed | map 04010 | TNF signaling | FOS, SOCS3, JUNB, CCL2 |