Fig. 1

α-cells undergo stage-selective global transcriptional changes after diphtheria toxin (DT)-induced β-cell loss. A Schematic of the transgenic mice used in this work. B Experimental design. α-cell lineage tracing was performed administering doxycycline for 2 weeks in the drinking water. After 2 additional weeks of DOX clearance, β-cells were ablated by intraperitoneal diphtheria toxin injections on days 1, 3 and 5. α-cells were purified at 5, 15 and 30 days post-DT injection (dpDT). C Hierarchical clustering analysis shows that the transcriptomes from stage-specific α-cell samples present higher correlation with biological replicates than with samples from other stages