Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth

BMC Genomics

Table 1 The seven CpGs on VTRNA2-1 with the largest differences in methylation between term and preterm samples (n = 10)

Target ID†	CHR	Position	Functional location	Mean β value in term samples (n = 5)	Mean β value in preterm samples (n = 5)	Difference*	p-value^a	q-value^b
cg26328633	5	135,416,394	TSS200	0.125	0.520	0.395	0.014	0.050
cg25340688	5	135,416,398	TSS200	0.121	0.508	0.387	0.014	0.050
cg06536614	5	135,416,381	TSS200	0.129	0.492	0.363	0.020	0.050
cg00124993	5	135,416,412	TSS200	0.114	0.471	0.357	0.014	0.050
cg26896946	5	135,416,405	TSS200	0.192	0.503	0.311	0.013	0.050
cg04481923	5	135,416,205	1stExon;3’UTR	0.122	0.389	0.267	0.015	0.050
cg18678645	5	135,416,331	TSS200	0.115	0.376	0.261	0.051	0.050

Gene ID of VTRNA2-1 is 100,126,299
CHR Chromosome
^aMann–Whitney U-test, p < 0.05
^bThe false discovery rate (FDR) was controlled using the Benjamini–Hochberg correction (q < 0.05)
†Name of the probe
*Difference between mean β values of preterm births and term births

ISSN: 1471-2164